Matches in SemOpenAlex for { <https://semopenalex.org/work/W1599697619> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1599697619 endingPage "5" @default.
- W1599697619 startingPage "3191" @default.
- W1599697619 abstract "Psorospermin, a cytotoxic dihydrofuranoxanthone isolated from Psorospermum febrifugum, produced aberrant simian virus 40 DNA replication intermediates when added to lytically infected CV-1 monkey kidney cells. The aberrant viral intermediates showed dose-dependent DNA strand breaks and protein-DNA cross-links, as well as decreased electrophoretic mobility. Simian virus 40 DNA from psorospermin-treated cells was shown to contain numerous abasic (apyrimidinic/apurinic) sites. The density of abasic sites was a function of the psorospermin dose. We conclude that psorospermin causes extensive loss of DNA bases in vivo. Primary amine groups of cellular proteins are known to react with abasic sites to form covalent protein-DNA cross-links and DNA strand breaks. Cytochrome c cross-linked spontaneously to viral DNA prepared from psorospermin-treated cells but not to DNA from untreated cells. This suggests that the protein-DNA cross-links and many of the DNA strand breaks observed in vivo result from reactions between abasic sites and chromosomal proteins. It is likely that the protein-DNA cross-links and DNA strand breaks contribute to the cytotoxicity and antineoplastic activity of psorospermin." @default.
- W1599697619 created "2016-06-24" @default.
- W1599697619 creator A5008317535 @default.
- W1599697619 creator A5031088440 @default.
- W1599697619 creator A5046462939 @default.
- W1599697619 creator A5084562482 @default.
- W1599697619 date "1994-06-15" @default.
- W1599697619 modified "2023-09-23" @default.
- W1599697619 title "Mechanism of action of the antileukemic xanthone psorospermin: DNA strand breaks, abasic sites, and protein-DNA cross-links." @default.
- W1599697619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8205539" @default.
- W1599697619 hasPublicationYear "1994" @default.
- W1599697619 type Work @default.
- W1599697619 sameAs 1599697619 @default.
- W1599697619 citedByCount "7" @default.
- W1599697619 countsByYear W15996976192015 @default.
- W1599697619 countsByYear W15996976192017 @default.
- W1599697619 countsByYear W15996976192018 @default.
- W1599697619 countsByYear W15996976192022 @default.
- W1599697619 crossrefType "journal-article" @default.
- W1599697619 hasAuthorship W1599697619A5008317535 @default.
- W1599697619 hasAuthorship W1599697619A5031088440 @default.
- W1599697619 hasAuthorship W1599697619A5046462939 @default.
- W1599697619 hasAuthorship W1599697619A5084562482 @default.
- W1599697619 hasConcept C104317684 @default.
- W1599697619 hasConcept C113271649 @default.
- W1599697619 hasConcept C134935766 @default.
- W1599697619 hasConcept C143425029 @default.
- W1599697619 hasConcept C150777479 @default.
- W1599697619 hasConcept C153911025 @default.
- W1599697619 hasConcept C156719811 @default.
- W1599697619 hasConcept C31254050 @default.
- W1599697619 hasConcept C552990157 @default.
- W1599697619 hasConcept C55493867 @default.
- W1599697619 hasConcept C67705224 @default.
- W1599697619 hasConcept C73573662 @default.
- W1599697619 hasConcept C86339819 @default.
- W1599697619 hasConcept C86803240 @default.
- W1599697619 hasConcept C94966510 @default.
- W1599697619 hasConceptScore W1599697619C104317684 @default.
- W1599697619 hasConceptScore W1599697619C113271649 @default.
- W1599697619 hasConceptScore W1599697619C134935766 @default.
- W1599697619 hasConceptScore W1599697619C143425029 @default.
- W1599697619 hasConceptScore W1599697619C150777479 @default.
- W1599697619 hasConceptScore W1599697619C153911025 @default.
- W1599697619 hasConceptScore W1599697619C156719811 @default.
- W1599697619 hasConceptScore W1599697619C31254050 @default.
- W1599697619 hasConceptScore W1599697619C552990157 @default.
- W1599697619 hasConceptScore W1599697619C55493867 @default.
- W1599697619 hasConceptScore W1599697619C67705224 @default.
- W1599697619 hasConceptScore W1599697619C73573662 @default.
- W1599697619 hasConceptScore W1599697619C86339819 @default.
- W1599697619 hasConceptScore W1599697619C86803240 @default.
- W1599697619 hasConceptScore W1599697619C94966510 @default.
- W1599697619 hasIssue "12" @default.
- W1599697619 hasLocation W15996976191 @default.
- W1599697619 hasOpenAccess W1599697619 @default.
- W1599697619 hasPrimaryLocation W15996976191 @default.
- W1599697619 hasRelatedWork W144486835 @default.
- W1599697619 hasRelatedWork W1599697619 @default.
- W1599697619 hasRelatedWork W2001005515 @default.
- W1599697619 hasRelatedWork W2037514688 @default.
- W1599697619 hasRelatedWork W2076705376 @default.
- W1599697619 hasRelatedWork W2123859422 @default.
- W1599697619 hasRelatedWork W2130806634 @default.
- W1599697619 hasRelatedWork W3209154032 @default.
- W1599697619 hasRelatedWork W4281679528 @default.
- W1599697619 hasRelatedWork W4289865920 @default.
- W1599697619 hasVolume "54" @default.
- W1599697619 isParatext "false" @default.
- W1599697619 isRetracted "false" @default.
- W1599697619 magId "1599697619" @default.
- W1599697619 workType "article" @default.