Matches in SemOpenAlex for { <https://semopenalex.org/work/W1599752942> ?p ?o ?g. }
- W1599752942 abstract "Abstract : Mutations in mitochondrial DNA (mtDNA) are frequent in prostate cancer and they seem to occur early during prostate malignant transformation. Depletion of mtDNA in prostate cancer cells has been linked to acquisition of androgenindependence, progression to an invasive phenotype that is resistant to conventional chemotherapies, as well as induction of epithelial-mesenchymal transition leading to cancer metastasis. Using long-range genomic polymerase chain reaction, large deletion of mtDNA can be detected in prostate cancer tissues but not benign or normal prostate tissues. Noticeably, our study excludes the germ-line origin of the mutant mtDNA pattern in prostate cancer patient through analysis of the blood of the corresponding patient. Our data conclude that mtDNA deletion is due to carcinogenesis process in somatic prostate cells. In addition, our data have unveiled the molecular alteration in prostate cancer cells resulted from mtDNA deletion. For example, Skp2 protein elevation is often associated in prostate cells with loss of mtDNA. Also, the presence of Skp2 expression can decrease the expression of BRCA2 protein as an early biomarker of prostate neoplastic transformation, which is due to BRCA2 proteolysis." @default.
- W1599752942 created "2016-06-24" @default.
- W1599752942 creator A5090605165 @default.
- W1599752942 date "2011-05-01" @default.
- W1599752942 modified "2023-09-23" @default.
- W1599752942 title "Suppression of BRCA2 by Mutant Mitochondrial DNA in Prostate Cancer" @default.
- W1599752942 cites W1501553911 @default.
- W1599752942 cites W1579403622 @default.
- W1599752942 cites W1914602388 @default.
- W1599752942 cites W1968515645 @default.
- W1599752942 cites W1972780353 @default.
- W1599752942 cites W1978427005 @default.
- W1599752942 cites W1981484848 @default.
- W1599752942 cites W1986528243 @default.
- W1599752942 cites W1988876415 @default.
- W1599752942 cites W1992887797 @default.
- W1599752942 cites W1994282776 @default.
- W1599752942 cites W1998007517 @default.
- W1599752942 cites W2001471842 @default.
- W1599752942 cites W2002223631 @default.
- W1599752942 cites W2004598694 @default.
- W1599752942 cites W2018649033 @default.
- W1599752942 cites W2018790123 @default.
- W1599752942 cites W2020235979 @default.
- W1599752942 cites W2040114786 @default.
- W1599752942 cites W2053354626 @default.
- W1599752942 cites W2060683430 @default.
- W1599752942 cites W2069912181 @default.
- W1599752942 cites W2071141495 @default.
- W1599752942 cites W2072276918 @default.
- W1599752942 cites W2073996456 @default.
- W1599752942 cites W2075296132 @default.
- W1599752942 cites W2084755054 @default.
- W1599752942 cites W2086040324 @default.
- W1599752942 cites W2088575891 @default.
- W1599752942 cites W2102570883 @default.
- W1599752942 cites W2107482866 @default.
- W1599752942 cites W2107633226 @default.
- W1599752942 cites W2122296279 @default.
- W1599752942 cites W2123322767 @default.
- W1599752942 cites W2127684282 @default.
- W1599752942 cites W2138064374 @default.
- W1599752942 cites W2141188843 @default.
- W1599752942 cites W2147345880 @default.
- W1599752942 cites W2148416479 @default.
- W1599752942 cites W2156871551 @default.
- W1599752942 cites W2163454545 @default.
- W1599752942 cites W3102970071 @default.
- W1599752942 doi "https://doi.org/10.21236/ada549344" @default.
- W1599752942 hasPublicationYear "2011" @default.
- W1599752942 type Work @default.
- W1599752942 sameAs 1599752942 @default.
- W1599752942 citedByCount "0" @default.
- W1599752942 crossrefType "report" @default.
- W1599752942 hasAuthorship W1599752942A5090605165 @default.
- W1599752942 hasConcept C104317684 @default.
- W1599752942 hasConcept C121608353 @default.
- W1599752942 hasConcept C134305767 @default.
- W1599752942 hasConcept C13514818 @default.
- W1599752942 hasConcept C150194340 @default.
- W1599752942 hasConcept C205003668 @default.
- W1599752942 hasConcept C24586158 @default.
- W1599752942 hasConcept C2776235491 @default.
- W1599752942 hasConcept C2779013556 @default.
- W1599752942 hasConcept C2779620337 @default.
- W1599752942 hasConcept C2780192828 @default.
- W1599752942 hasConcept C2909462720 @default.
- W1599752942 hasConcept C501734568 @default.
- W1599752942 hasConcept C502942594 @default.
- W1599752942 hasConcept C54355233 @default.
- W1599752942 hasConcept C555283112 @default.
- W1599752942 hasConcept C86803240 @default.
- W1599752942 hasConcept C87874733 @default.
- W1599752942 hasConceptScore W1599752942C104317684 @default.
- W1599752942 hasConceptScore W1599752942C121608353 @default.
- W1599752942 hasConceptScore W1599752942C134305767 @default.
- W1599752942 hasConceptScore W1599752942C13514818 @default.
- W1599752942 hasConceptScore W1599752942C150194340 @default.
- W1599752942 hasConceptScore W1599752942C205003668 @default.
- W1599752942 hasConceptScore W1599752942C24586158 @default.
- W1599752942 hasConceptScore W1599752942C2776235491 @default.
- W1599752942 hasConceptScore W1599752942C2779013556 @default.
- W1599752942 hasConceptScore W1599752942C2779620337 @default.
- W1599752942 hasConceptScore W1599752942C2780192828 @default.
- W1599752942 hasConceptScore W1599752942C2909462720 @default.
- W1599752942 hasConceptScore W1599752942C501734568 @default.
- W1599752942 hasConceptScore W1599752942C502942594 @default.
- W1599752942 hasConceptScore W1599752942C54355233 @default.
- W1599752942 hasConceptScore W1599752942C555283112 @default.
- W1599752942 hasConceptScore W1599752942C86803240 @default.
- W1599752942 hasConceptScore W1599752942C87874733 @default.
- W1599752942 hasLocation W15997529421 @default.
- W1599752942 hasOpenAccess W1599752942 @default.
- W1599752942 hasPrimaryLocation W15997529421 @default.
- W1599752942 hasRelatedWork W1504730049 @default.
- W1599752942 hasRelatedWork W1970841420 @default.
- W1599752942 hasRelatedWork W1976149964 @default.
- W1599752942 hasRelatedWork W1992294319 @default.
- W1599752942 hasRelatedWork W2006291400 @default.
- W1599752942 hasRelatedWork W2034549847 @default.