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- W1599816548 abstract "Summary Oxidation of butyric acid-14C and palmitic acid-14C to CO2 and acetoacetic acid was studied in fortified homogenates of a variety of transplantable rat liver tumors. Both fatty acids were oxidized readily by the so-called “minimal deviation” hepatomas, the Morris 5123, 7793, and 7787 tumors, to a much lesser extent by the Reuber H-35 and Morris 7288C tumors, and hardly at all by the Morris 3924A and 3683 tumors and the Novikoff hepatoma. The ratio of fatty acid oxidation to CO2 and to acetoacetate varied widely; for the most part, though, there was a resemblance to the pattern displayed by liver, in those tumors which oxidized the fatty acids. In general there was a reciprocal relationship between the ability to oxidize fatty acids and the ability to phosphorylate glucose. Those tumors which grew slowly and lacked the capability for glucose phosphorylation readily oxidized fatty acids, whereas the high glycolyzing tumors failed to oxidize fatty acids. Randomization of 14C label from butyrate-3-14C into carbons 1 and 3 of acetoacetate occurred in all tumors that oxidized butyrate, pointing to the presence in these tumors of the same complex of enzymes for fatty acid oxidation as occurs in liver." @default.
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- W1599816548 date "1965-01-01" @default.
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- W1599816548 title "Fatty acid oxidation and ketogenesis in transplantable liver tumors" @default.
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- W1599816548 doi "https://doi.org/10.1016/0065-2571(65)90063-4" @default.
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