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- W1599888945 abstract "Some cells have to be eliminated in an organism to keep the homeostasis, tissue remodelling or embrionary development. This process is known as programmed cell death or apoptosis. Apoptosis is a dynamic process in which a cascade of events appear at different times. Apoptosis can be induced by various stimuli, such as DNA damage, cytokines, loss of extracellular matrix, etc. Apoptosis detection has become very important in cancer, since it is helpful to understand carcinogenesis, mechanisms of chemotherapy drugs, evaluation of treatment response, etc. Importantly, apoptosis detection depends on the moment the cells or tissues are studied. The most common events used to detect apoptosis include the identification of DNA degradation by gel electrophoresis, changes on the cytoplasmic membrane and activation of specific proteins. The aim of this article is to describe the main techniques used for detection of apoptosis, and their limitations. The criteria described in this paper pretend to help to choose the most convenient method for apoptosis detection." @default.
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- W1599888945 date "2000-01-01" @default.
- W1599888945 modified "2023-09-26" @default.
- W1599888945 title "Métodos de detección de la apoptosis, aplicaciones y limitaciones" @default.
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