Matches in SemOpenAlex for { <https://semopenalex.org/work/W1600034319> ?p ?o ?g. }
- W1600034319 endingPage "1151" @default.
- W1600034319 startingPage "1146" @default.
- W1600034319 abstract "Abstract Somatic hypermutation (SHM) of the rearranged Ig genes is required for the affinity maturation of Abs. SHM is almost exclusively targeted to the rearranged Ig loci, but the mechanism of this gene-specific targeting remains unclear. The Ig κ L chain locus contains multiple enhancers, including the MAR/intronic (iEκ) and 3′ enhancers (3′Eκ). Previous transgenic studies indicate that both κ enhancers are individually necessary for SHM of Igk. In contrast, later studies of Ag-selected Vκ genes in 3′Eκ−/− mice found no absolute requirement for 3′Eκ in κ SHM. To address the roles of the two κ enhancers in SHM in a physiological context, we analyzed SHM of the endogenous Igk in mice with a targeted deletion of either iEκ or 3′Eκ in Peyer’s patch germinal center B cells. Our findings indicate that, although 3′Eκ is quantitatively important for SHM of Igk, iEκ is not required for κ SHM. In addition, a reduction of κ mRNA levels is also detected in activated 3′Eκ−/− B cells. These findings suggest that iEκ and 3′Eκ play distinct roles in regulating Igk transcription and SHM." @default.
- W1600034319 created "2016-06-24" @default.
- W1600034319 creator A5004111575 @default.
- W1600034319 creator A5027306221 @default.
- W1600034319 creator A5033263569 @default.
- W1600034319 creator A5081369680 @default.
- W1600034319 creator A5088151758 @default.
- W1600034319 creator A5091160712 @default.
- W1600034319 date "2006-07-15" @default.
- W1600034319 modified "2023-09-27" @default.
- W1600034319 title "Roles of the Ig κ Light Chain Intronic and 3′ Enhancers in <i>Igk</i> Somatic Hypermutation" @default.
- W1600034319 cites W1541136838 @default.
- W1600034319 cites W1556562072 @default.
- W1600034319 cites W1607787817 @default.
- W1600034319 cites W1824817514 @default.
- W1600034319 cites W1893492423 @default.
- W1600034319 cites W1964459498 @default.
- W1600034319 cites W1971344703 @default.
- W1600034319 cites W1981239551 @default.
- W1600034319 cites W1989735636 @default.
- W1600034319 cites W1990793482 @default.
- W1600034319 cites W2006561130 @default.
- W1600034319 cites W2006573531 @default.
- W1600034319 cites W2016913332 @default.
- W1600034319 cites W2037404852 @default.
- W1600034319 cites W2038589622 @default.
- W1600034319 cites W2048517129 @default.
- W1600034319 cites W2050582521 @default.
- W1600034319 cites W2053572117 @default.
- W1600034319 cites W2059557296 @default.
- W1600034319 cites W2067016089 @default.
- W1600034319 cites W2072149435 @default.
- W1600034319 cites W2080160687 @default.
- W1600034319 cites W2109980231 @default.
- W1600034319 cites W2109984445 @default.
- W1600034319 cites W2125409137 @default.
- W1600034319 cites W2125718036 @default.
- W1600034319 cites W2129883110 @default.
- W1600034319 cites W2130443206 @default.
- W1600034319 cites W2141204992 @default.
- W1600034319 cites W2145049710 @default.
- W1600034319 cites W2146949661 @default.
- W1600034319 cites W2152078686 @default.
- W1600034319 cites W2159133915 @default.
- W1600034319 cites W2221403975 @default.
- W1600034319 cites W2265566129 @default.
- W1600034319 cites W91948647 @default.
- W1600034319 doi "https://doi.org/10.4049/jimmunol.177.2.1146" @default.
- W1600034319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16818772" @default.
- W1600034319 hasPublicationYear "2006" @default.
- W1600034319 type Work @default.
- W1600034319 sameAs 1600034319 @default.
- W1600034319 citedByCount "44" @default.
- W1600034319 countsByYear W16000343192012 @default.
- W1600034319 countsByYear W16000343192013 @default.
- W1600034319 countsByYear W16000343192014 @default.
- W1600034319 countsByYear W16000343192015 @default.
- W1600034319 countsByYear W16000343192016 @default.
- W1600034319 countsByYear W16000343192018 @default.
- W1600034319 countsByYear W16000343192019 @default.
- W1600034319 countsByYear W16000343192020 @default.
- W1600034319 countsByYear W16000343192022 @default.
- W1600034319 countsByYear W16000343192023 @default.
- W1600034319 crossrefType "journal-article" @default.
- W1600034319 hasAuthorship W1600034319A5004111575 @default.
- W1600034319 hasAuthorship W1600034319A5027306221 @default.
- W1600034319 hasAuthorship W1600034319A5033263569 @default.
- W1600034319 hasAuthorship W1600034319A5081369680 @default.
- W1600034319 hasAuthorship W1600034319A5088151758 @default.
- W1600034319 hasAuthorship W1600034319A5091160712 @default.
- W1600034319 hasBestOaLocation W16000343191 @default.
- W1600034319 hasConcept C104317684 @default.
- W1600034319 hasConcept C111936080 @default.
- W1600034319 hasConcept C128526571 @default.
- W1600034319 hasConcept C134305767 @default.
- W1600034319 hasConcept C153911025 @default.
- W1600034319 hasConcept C159654299 @default.
- W1600034319 hasConcept C2778453870 @default.
- W1600034319 hasConcept C36394416 @default.
- W1600034319 hasConcept C54355233 @default.
- W1600034319 hasConcept C86339819 @default.
- W1600034319 hasConcept C86803240 @default.
- W1600034319 hasConcept C96926380 @default.
- W1600034319 hasConceptScore W1600034319C104317684 @default.
- W1600034319 hasConceptScore W1600034319C111936080 @default.
- W1600034319 hasConceptScore W1600034319C128526571 @default.
- W1600034319 hasConceptScore W1600034319C134305767 @default.
- W1600034319 hasConceptScore W1600034319C153911025 @default.
- W1600034319 hasConceptScore W1600034319C159654299 @default.
- W1600034319 hasConceptScore W1600034319C2778453870 @default.
- W1600034319 hasConceptScore W1600034319C36394416 @default.
- W1600034319 hasConceptScore W1600034319C54355233 @default.
- W1600034319 hasConceptScore W1600034319C86339819 @default.
- W1600034319 hasConceptScore W1600034319C86803240 @default.
- W1600034319 hasConceptScore W1600034319C96926380 @default.
- W1600034319 hasIssue "2" @default.
- W1600034319 hasLocation W16000343191 @default.
- W1600034319 hasLocation W16000343192 @default.