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- W1600109898 abstract "The basic concept of the immune system postulates an ability to discriminate between self and non-self and to free the organism from the latter. Two major contributions advanced the comprehension of the cellular basis of self- versus non-self-discrimination. The first was the hypothesis regarding the expansion of antigen-recognising clones on encounter with a respective antigen, which allowed antigenic specificities of the resulting immune reactions to be explained. The co-stimulatory signal hypothesis represented another essential advancement. It postulated the necessity of a second, antigen-independent signal for lymphocyte activation. Its nature was put into an elegant metaphor of the ‘immunologist's dirty little secret’ [1], referring to substances of microbial origin that should be present concomitant with an antigen to prime an immune response to it." @default.
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- W1600109898 date "2005-07-18" @default.
- W1600109898 modified "2023-09-26" @default.
- W1600109898 title "Toll-Like Receptor-Dependent Activation of Antigen Presenting Cells by Hsp60, gp96 and Hsp70" @default.
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- W1600109898 doi "https://doi.org/10.1017/cbo9780511546310.008" @default.
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