FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1600112536> ?p ?o ?g. }

• W1600112536 abstract "Breast cancer is of a primary concern in women, although it can occur in men. It is the second leading cause of cancer related deaths amongst women, and it is estimated that roughly 39,840 women will die of this disease this year. Breast cancer occurs across all populations and ethnicities. When African-Americans (AA) present with breast cancer, they usually have poorly differentiated tumors, and are more likely to be diagnosed with an advanced stage tumor. When compared to Caucasian (Cau) women, African-American women also have higher breast cancer mortality. The causes of these differences are not yet definitively known, but it has been suggested that the disparities that are present between African-American and Caucasian women are due to a number of factors. A few which have been mentioned are differences in Body Mass Index (BMI), socioeconomic status, health care coverage, and the level of obtained education that exists between the two ethnic groups. Although these factors may account for a small percentage of the difference seen between the two ethnic groups, the underlying cause that may explain why African-American women are at a greater risk of developing aggressive breast cancer may be due to differences in gene expression. A focus of my research project is the comparison of genome-wide gene expression differences between African-American and Caucasian women. Preliminary results from the comparison of normal breast tissue (obtained from reduction mammoplasty) from Caucasian and African-American women suggest there are marked differences in gene expression patterns. Pathway analysis of differentially expressed genes shows that they are involved in protein folding and the immune response. I am currently expanding this study to include a comparison of 10 AA to 10 Cau normal breast samples. These samples are being LCM dissected to separately compare gene expression in epithelial and stromal tissue. Cross comparisons between ethnic groups and tissue types will provide an understanding of normally occurring differences between AA and Cau women, which may help to explain the observed cancer disparities. Data from the study of normal tissue will be compared to gene expression data from triple negative breast cancer (TNBC) patients from both ethnicities." @default.
• W1600112536 created "2016-06-24" @default.
• W1600112536 creator A5069500328 @default.
• W1600112536 date "2011-10-21" @default.
• W1600112536 modified "2023-09-23" @default.
• W1600112536 title "Examination of Genetic Changes Associated with Breast Cancer Disparities Across Multiple Ethnicities" @default.
• W1600112536 cites W1601076886 @default.
• W1600112536 cites W1839791863 @default.
• W1600112536 cites W1963891653 @default.
• W1600112536 cites W1995224853 @default.
• W1600112536 cites W2001575298 @default.
• W1600112536 cites W2010871781 @default.
• W1600112536 cites W2016056895 @default.
• W1600112536 cites W2021129827 @default.
• W1600112536 cites W2034269086 @default.
• W1600112536 cites W2042611635 @default.
• W1600112536 cites W2046264434 @default.
• W1600112536 cites W2050818040 @default.
• W1600112536 cites W2065249063 @default.
• W1600112536 cites W2074494628 @default.
• W1600112536 cites W2083466846 @default.
• W1600112536 cites W2099814623 @default.
• W1600112536 cites W2104045436 @default.
• W1600112536 cites W2120064570 @default.
• W1600112536 cites W2120865735 @default.
• W1600112536 cites W2122197597 @default.
• W1600112536 cites W2128967720 @default.
• W1600112536 cites W2148788638 @default.
• W1600112536 cites W2150926065 @default.
• W1600112536 cites W2157840751 @default.
• W1600112536 cites W2158734599 @default.
• W1600112536 cites W2160928966 @default.
• W1600112536 cites W2164961968 @default.
• W1600112536 cites W185134482 @default.
• W1600112536 hasPublicationYear "2011" @default.
• W1600112536 type Work @default.
• W1600112536 sameAs 1600112536 @default.
• W1600112536 citedByCount "0" @default.
• W1600112536 crossrefType "journal-article" @default.
• W1600112536 hasAuthorship W1600112536A5069500328 @default.
• W1600112536 hasConcept C121608353 @default.
• W1600112536 hasConcept C126322002 @default.
• W1600112536 hasConcept C137403100 @default.
• W1600112536 hasConcept C138816342 @default.
• W1600112536 hasConcept C142724271 @default.
• W1600112536 hasConcept C143998085 @default.
• W1600112536 hasConcept C144024400 @default.
• W1600112536 hasConcept C147077947 @default.
• W1600112536 hasConcept C149923435 @default.
• W1600112536 hasConcept C19165224 @default.
• W1600112536 hasConcept C2250968 @default.
• W1600112536 hasConcept C2779134260 @default.
• W1600112536 hasConcept C2780221984 @default.
• W1600112536 hasConcept C2908647359 @default.
• W1600112536 hasConcept C29456083 @default.
• W1600112536 hasConcept C530470458 @default.
• W1600112536 hasConcept C71924100 @default.
• W1600112536 hasConcept C74909509 @default.
• W1600112536 hasConcept C99454951 @default.
• W1600112536 hasConceptScore W1600112536C121608353 @default.
• W1600112536 hasConceptScore W1600112536C126322002 @default.
• W1600112536 hasConceptScore W1600112536C137403100 @default.
• W1600112536 hasConceptScore W1600112536C138816342 @default.
• W1600112536 hasConceptScore W1600112536C142724271 @default.
• W1600112536 hasConceptScore W1600112536C143998085 @default.
• W1600112536 hasConceptScore W1600112536C144024400 @default.
• W1600112536 hasConceptScore W1600112536C147077947 @default.
• W1600112536 hasConceptScore W1600112536C149923435 @default.
• W1600112536 hasConceptScore W1600112536C19165224 @default.
• W1600112536 hasConceptScore W1600112536C2250968 @default.
• W1600112536 hasConceptScore W1600112536C2779134260 @default.
• W1600112536 hasConceptScore W1600112536C2780221984 @default.
• W1600112536 hasConceptScore W1600112536C2908647359 @default.
• W1600112536 hasConceptScore W1600112536C29456083 @default.
• W1600112536 hasConceptScore W1600112536C530470458 @default.
• W1600112536 hasConceptScore W1600112536C71924100 @default.
• W1600112536 hasConceptScore W1600112536C74909509 @default.
• W1600112536 hasConceptScore W1600112536C99454951 @default.
• W1600112536 hasLocation W16001125361 @default.
• W1600112536 hasOpenAccess W1600112536 @default.
• W1600112536 hasPrimaryLocation W16001125361 @default.
• W1600112536 hasRelatedWork W1487698176 @default.
• W1600112536 hasRelatedWork W1968330954 @default.
• W1600112536 hasRelatedWork W1998680775 @default.
• W1600112536 hasRelatedWork W20341848 @default.
• W1600112536 hasRelatedWork W2082359442 @default.
• W1600112536 hasRelatedWork W2097006472 @default.
• W1600112536 hasRelatedWork W2105906267 @default.
• W1600112536 hasRelatedWork W2144634511 @default.
• W1600112536 hasRelatedWork W2155909990 @default.
• W1600112536 hasRelatedWork W2160423641 @default.
• W1600112536 hasRelatedWork W2345354028 @default.
• W1600112536 hasRelatedWork W2396859386 @default.
• W1600112536 hasRelatedWork W2401246105 @default.
• W1600112536 hasRelatedWork W2483530229 @default.
• W1600112536 hasRelatedWork W2783194264 @default.
• W1600112536 hasRelatedWork W2970683173 @default.
• W1600112536 hasRelatedWork W2970683741 @default.
• W1600112536 hasRelatedWork W3116163132 @default.
• W1600112536 hasRelatedWork W3205146723 @default.

• next