FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1600168077> ?p ?o ?g. }

• W1600168077 endingPage "814" @default.
• W1600168077 startingPage "804" @default.
• W1600168077 abstract "BACKGROUND AND PURPOSE Erectile dysfunction correlates with cardiovascular disease and its common risk factors due to the development of endothelial dysfunction. Positive effects on endothelial and erectile function have been described for substances inhibiting the renin‐angiotensin‐system. Here, we investigated in an atherosclerosis model, whether telmisartan (angiotensin receptor blocker) and ramipril (angiotensin converting enzyme inhibitor) are equivalent or the combination of both is superior in improving endothelial function in the aorta and the corpus cavernosum and in reducing atherosclerosis. EXPERIMENTAL APPROACH Wild‐type (WT, C57/B6) and apolipoprotein‐E‐deficient (ApoE −/− ) mice were treated with a cholesterol‐rich diet for 8 weeks. ApoE −/− mice were supplemented with either telmisartan (20 mg·kg −1 ·day −1 ), ramipril (2.5 mg·kg −1 ·day −1 ) or the combination thereof. KEY RESULTS Systolic blood pressure significantly decreased in treatment groups ( P < 0.001), with significantly smaller reduction under ramipril monotherapy ( P < 0.05). Endothelial function (assessed by pharmacological stimulation of aortic rings and corpus cavernosum in organ bath chambers) was impaired in ApoE −/− mice compared to WT animals, which was improved by all three treatments to a comparable extent ( P < 0.05). Atherosclerotic lesion size in the ascending aorta and aortic sinus ( P < 0.001), the amount of lipid peroxides in cavernosal and aortic tissue ( P < 0.05) and free radical load (dihydroethidium‐stain) ( P < 0.05) were enhanced in untreated ApoE −/− mice in comparison to WT animals and were significantly reduced by either treatment. In penile tissue, expression of eNOS could be restored by renin‐angiotensin‐aldosterone system blockade. CONCLUSIONS AND IMPLICATIONS Telmisartan and ramipril significantly improved endothelial function of aortic and cavernosal tissues in ApoE −/− via reduction of oxidative stress. Combination of both agents does not enhance beneficial effects significantly." @default.
• W1600168077 created "2016-06-24" @default.
• W1600168077 creator A5014343012 @default.
• W1600168077 creator A5044248842 @default.
• W1600168077 creator A5066606742 @default.
• W1600168077 creator A5073143497 @default.
• W1600168077 date "2011-05-26" @default.
• W1600168077 modified "2023-10-18" @default.
• W1600168077 title "Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol-induced atherosclerosis" @default.
• W1600168077 cites W1543887304 @default.
• W1600168077 cites W1590368091 @default.
• W1600168077 cites W1966415714 @default.
• W1600168077 cites W1976555160 @default.
• W1600168077 cites W1977505869 @default.
• W1600168077 cites W1982488339 @default.
• W1600168077 cites W1983392853 @default.
• W1600168077 cites W1984533748 @default.
• W1600168077 cites W1984700685 @default.
• W1600168077 cites W1991518573 @default.
• W1600168077 cites W2008409001 @default.
• W1600168077 cites W2018398381 @default.
• W1600168077 cites W2023158378 @default.
• W1600168077 cites W2024626357 @default.
• W1600168077 cites W2030099266 @default.
• W1600168077 cites W2040141893 @default.
• W1600168077 cites W2044183408 @default.
• W1600168077 cites W2044635352 @default.
• W1600168077 cites W2046598678 @default.
• W1600168077 cites W2052055930 @default.
• W1600168077 cites W2070316487 @default.
• W1600168077 cites W2071388820 @default.
• W1600168077 cites W2074393549 @default.
• W1600168077 cites W2080907400 @default.
• W1600168077 cites W2083444947 @default.
• W1600168077 cites W2097933156 @default.
• W1600168077 cites W2105464027 @default.
• W1600168077 cites W2108892645 @default.
• W1600168077 cites W2109156184 @default.
• W1600168077 cites W2110182057 @default.
• W1600168077 cites W2110362194 @default.
• W1600168077 cites W2111494287 @default.
• W1600168077 cites W2112656429 @default.
• W1600168077 cites W2123095204 @default.
• W1600168077 cites W2133638738 @default.
• W1600168077 cites W2133863398 @default.
• W1600168077 cites W2141641708 @default.
• W1600168077 cites W2152798629 @default.
• W1600168077 cites W2159383994 @default.
• W1600168077 cites W2160643831 @default.
• W1600168077 cites W2168975002 @default.
• W1600168077 cites W4243770305 @default.
• W1600168077 cites W4317523496 @default.
• W1600168077 doi "https://doi.org/10.1111/j.1476-5381.2011.01267.x" @default.
• W1600168077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3111682" @default.
• W1600168077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21323898" @default.
• W1600168077 hasPublicationYear "2011" @default.
• W1600168077 type Work @default.
• W1600168077 sameAs 1600168077 @default.
• W1600168077 citedByCount "24" @default.
• W1600168077 countsByYear W16001680772012 @default.
• W1600168077 countsByYear W16001680772013 @default.
• W1600168077 countsByYear W16001680772014 @default.
• W1600168077 countsByYear W16001680772015 @default.
• W1600168077 countsByYear W16001680772016 @default.
• W1600168077 countsByYear W16001680772017 @default.
• W1600168077 countsByYear W16001680772018 @default.
• W1600168077 countsByYear W16001680772020 @default.
• W1600168077 crossrefType "journal-article" @default.
• W1600168077 hasAuthorship W1600168077A5014343012 @default.
• W1600168077 hasAuthorship W1600168077A5044248842 @default.
• W1600168077 hasAuthorship W1600168077A5066606742 @default.
• W1600168077 hasAuthorship W1600168077A5073143497 @default.
• W1600168077 hasBestOaLocation W16001680772 @default.
• W1600168077 hasConcept C126322002 @default.
• W1600168077 hasConcept C134018914 @default.
• W1600168077 hasConcept C198710026 @default.
• W1600168077 hasConcept C27016395 @default.
• W1600168077 hasConcept C2777622882 @default.
• W1600168077 hasConcept C2778326061 @default.
• W1600168077 hasConcept C2779134260 @default.
• W1600168077 hasConcept C2779611605 @default.
• W1600168077 hasConcept C2779716603 @default.
• W1600168077 hasConcept C2779888176 @default.
• W1600168077 hasConcept C2779980429 @default.
• W1600168077 hasConcept C2780972559 @default.
• W1600168077 hasConcept C2908929049 @default.
• W1600168077 hasConcept C519581460 @default.
• W1600168077 hasConcept C57089818 @default.
• W1600168077 hasConcept C71924100 @default.
• W1600168077 hasConcept C84393581 @default.
• W1600168077 hasConceptScore W1600168077C126322002 @default.
• W1600168077 hasConceptScore W1600168077C134018914 @default.
• W1600168077 hasConceptScore W1600168077C198710026 @default.
• W1600168077 hasConceptScore W1600168077C27016395 @default.
• W1600168077 hasConceptScore W1600168077C2777622882 @default.
• W1600168077 hasConceptScore W1600168077C2778326061 @default.
• W1600168077 hasConceptScore W1600168077C2779134260 @default.
• W1600168077 hasConceptScore W1600168077C2779611605 @default.

• next