FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1600219967> ?p ?o ?g. }

• W1600219967 endingPage "173" @default.
• W1600219967 startingPage "165" @default.
• W1600219967 abstract "Carcinomas of the biliary tract are aggressive malignancies in humans. Loss of the tumour suppressor PTEN has previously been associated with cholangiocarcinoma development in a murine model. Activation of KRAS is reported in up to one-third of human cholangiocarcinomas and 50% of gall bladder carcinomas. In this study we aimed to test the potential interaction between PTEN and KRAS mutation in biliary tract malignancy. We used an inducible Cre-LoxP-based approach to coordinately delete PTEN and activate KRAS within the adult mouse biliary epithelium. We found that activation of KRAS alone has little effect upon biliary epithelium. Loss of PTEN alone results in the development of low-grade neoplastic lesions, following long latency and at low incidence. Combination of both mutations causes rapid development of biliary epithelial proliferative lesions, which progress through dysplasia to invasive carcinoma. We conclude that activation of the PI3'K pathway following loss of PTEN is sufficient to drive slow development of low-grade biliary lesions in mice. In contrast, mutational activation of KRAS does not result in a similar phenotype, despite a prediction that this should activate both the RAF-MEK-ERK and PI3'-kinase pathways. However, mutation of both genes results in rapid tumourigenesis, arguing that PTEN normally functions as a 'brake' on the PI3'-kinase pathway, limiting the influence of KRAS activation. Mutation of both genes creates a 'permissive' environment, allowing the full effects of both mutations to be manifested. These data reveal an in vivo synergy between these mutations and provides a new mouse model of biliary tract malignancy." @default.
• W1600219967 created "2016-06-24" @default.
• W1600219967 creator A5001013132 @default.
• W1600219967 creator A5028820548 @default.
• W1600219967 creator A5036404350 @default.
• W1600219967 creator A5042462909 @default.
• W1600219967 date "2013-05-13" @default.
• W1600219967 modified "2023-09-24" @default.
• W1600219967 title "PTEN loss and KRAS activation cooperate in murine biliary tract malignancies" @default.
• W1600219967 cites W1768274470 @default.
• W1600219967 cites W1981051246 @default.
• W1600219967 cites W1998038367 @default.
• W1600219967 cites W1998759761 @default.
• W1600219967 cites W2005180405 @default.
• W1600219967 cites W2013377366 @default.
• W1600219967 cites W2017191360 @default.
• W1600219967 cites W2026674119 @default.
• W1600219967 cites W2053047279 @default.
• W1600219967 cites W2059634098 @default.
• W1600219967 cites W2062495971 @default.
• W1600219967 cites W2068345721 @default.
• W1600219967 cites W2077297619 @default.
• W1600219967 cites W2082888699 @default.
• W1600219967 cites W2083695927 @default.
• W1600219967 cites W2099942653 @default.
• W1600219967 cites W2104541549 @default.
• W1600219967 cites W2110825909 @default.
• W1600219967 cites W2110999558 @default.
• W1600219967 cites W2130397221 @default.
• W1600219967 cites W2141956267 @default.
• W1600219967 cites W2149247743 @default.
• W1600219967 cites W2149431131 @default.
• W1600219967 cites W2158860569 @default.
• W1600219967 cites W2161810908 @default.
• W1600219967 cites W2172258358 @default.
• W1600219967 cites W2016411184 @default.
• W1600219967 doi "https://doi.org/10.1002/path.4189" @default.
• W1600219967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23483557" @default.
• W1600219967 hasPublicationYear "2013" @default.
• W1600219967 type Work @default.
• W1600219967 sameAs 1600219967 @default.
• W1600219967 citedByCount "32" @default.
• W1600219967 countsByYear W16002199672014 @default.
• W1600219967 countsByYear W16002199672015 @default.
• W1600219967 countsByYear W16002199672016 @default.
• W1600219967 countsByYear W16002199672017 @default.
• W1600219967 countsByYear W16002199672018 @default.
• W1600219967 countsByYear W16002199672019 @default.
• W1600219967 countsByYear W16002199672020 @default.
• W1600219967 countsByYear W16002199672021 @default.
• W1600219967 countsByYear W16002199672022 @default.
• W1600219967 countsByYear W16002199672023 @default.
• W1600219967 crossrefType "journal-article" @default.
• W1600219967 hasAuthorship W1600219967A5001013132 @default.
• W1600219967 hasAuthorship W1600219967A5028820548 @default.
• W1600219967 hasAuthorship W1600219967A5036404350 @default.
• W1600219967 hasAuthorship W1600219967A5042462909 @default.
• W1600219967 hasConcept C121608353 @default.
• W1600219967 hasConcept C126322002 @default.
• W1600219967 hasConcept C2775982439 @default.
• W1600219967 hasConcept C2777609662 @default.
• W1600219967 hasConcept C2781187634 @default.
• W1600219967 hasConcept C502942594 @default.
• W1600219967 hasConcept C526805850 @default.
• W1600219967 hasConcept C54355233 @default.
• W1600219967 hasConcept C555283112 @default.
• W1600219967 hasConcept C62478195 @default.
• W1600219967 hasConcept C71924100 @default.
• W1600219967 hasConcept C86554907 @default.
• W1600219967 hasConcept C86803240 @default.
• W1600219967 hasConcept C95444343 @default.
• W1600219967 hasConceptScore W1600219967C121608353 @default.
• W1600219967 hasConceptScore W1600219967C126322002 @default.
• W1600219967 hasConceptScore W1600219967C2775982439 @default.
• W1600219967 hasConceptScore W1600219967C2777609662 @default.
• W1600219967 hasConceptScore W1600219967C2781187634 @default.
• W1600219967 hasConceptScore W1600219967C502942594 @default.
• W1600219967 hasConceptScore W1600219967C526805850 @default.
• W1600219967 hasConceptScore W1600219967C54355233 @default.
• W1600219967 hasConceptScore W1600219967C555283112 @default.
• W1600219967 hasConceptScore W1600219967C62478195 @default.
• W1600219967 hasConceptScore W1600219967C71924100 @default.
• W1600219967 hasConceptScore W1600219967C86554907 @default.
• W1600219967 hasConceptScore W1600219967C86803240 @default.
• W1600219967 hasConceptScore W1600219967C95444343 @default.
• W1600219967 hasIssue "2" @default.
• W1600219967 hasLocation W16002199671 @default.
• W1600219967 hasLocation W16002199672 @default.
• W1600219967 hasOpenAccess W1600219967 @default.
• W1600219967 hasPrimaryLocation W16002199671 @default.
• W1600219967 hasRelatedWork W1600219967 @default.
• W1600219967 hasRelatedWork W1601243762 @default.
• W1600219967 hasRelatedWork W2106300588 @default.
• W1600219967 hasRelatedWork W2195355178 @default.
• W1600219967 hasRelatedWork W2360478690 @default.
• W1600219967 hasRelatedWork W2500217852 @default.
• W1600219967 hasRelatedWork W2566402427 @default.
• W1600219967 hasRelatedWork W2736114290 @default.

• next