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- W1600314 abstract "It has been shown that depakin, a GABA-ergic agonist, and alpha-methyl-DOPA that inhibits catecholamine synthesis are capable of removing the withdrawal syndrome (disturbed pavlovian behavior pattern and aggressiveness) occurring after discontinuance of long-term administration (30 days) of phenazepam to rats in a dose of 2 mg/kg. In contrast, bicucullin, a blocker of GABA-ergic receptors, thiosemicarbazide that inhibits GABA synthesis by the brain, disulfiram and 3,4-dioxyphenylalanine that increase dopamine and noradrenaline content in the barain aggravate the withdrawal syndrome after phenazepam is discontinued. The data obtained suggest a role of GABA-ergic and dopaminergic mechanisms in the emergence of the withdrawal syndrome after discontinuance of long-term administration of benzdiazepins." @default.
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- W1600314 date "1980-07-01" @default.
- W1600314 modified "2023-09-23" @default.
- W1600314 title "[Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration]." @default.
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