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- W1600604076 abstract "Summary Disruption of mast cells by the administration of distilled water, polymyxin B, compound 48/80, or tumor polypeptide derived from rat sarcoma produced alterations in I131 distribution similar to those seen in a tumor-bearing animal. Injection of two of the known mast cell components, histamine and 5-HT, also caused this alteration, called iodide trapping. Heparin had no activity in this respect. Reserpine, because of its ability to release 5-HT from the body, produced the trapping syndrome. These factors, together with the knowledge that growth of the tumor causes a progressive, widespread decrease in the number of intact mast cells, indicate that the release of histamine and/or 5-HT resulting from this disruption of mast cells may be responsible for the iodide trapping observed in the tumor-bearing animal." @default.
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- W1600604076 date "1958-09-01" @default.
- W1600604076 modified "2023-09-23" @default.
- W1600604076 title "Mast-cell disruption and I 131 distribution in the rat." @default.
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