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• W1600619114 startingPage "210" @default.
• W1600619114 abstract "The relative importance of mitochondria, the Na+/Ca2+ exchanger (NCX) and the endoplasmic reticulum (ER) in the regulation of the cytosolic Ca2+ concentration ([Ca2+]i) were examined in bovine chromaffin cells using fura-2 for average [Ca2+]i and amperometry for secretory activity, which reflects the local Ca2+ concentration near the exocytotic sites. Chromaffin cells were stimulated by a high concentration of K+ when the three Ca2+ removal mechanisms were individually or simultaneously inhibited. When the mitochondrial Ca2+ uptake was inhibited, the [Ca2+]i decayed at a significantly slower rate and the secretory activity was higher than the control cells. The NCX appears to function only in the initial phase of [Ca2+]i decay and when the ER Ca2+ pump is blocked. Similarly, the ER had a significant effect on the [Ca2+]i decay and on the secretion only when the NCX was blocked. Inhibition of all three mechanisms leads to a substantial delay in [Ca2+]i recovery and an increase in the secretion. The results suggest that the three mechanisms work together in the regulation of the Ca2+ near the Ca2+ channels and exocytotic sites and therefore modulate the secretory activity. When Ca2+ diffuses away from the exocytotic sites, the mitochondrial Ca2+ uptake becomes the dominant mechanism." @default.
• W1600619114 created "2016-06-24" @default.
• W1600619114 creator A5004393843 @default.
• W1600619114 creator A5037204378 @default.
• W1600619114 date "2008-10-10" @default.
• W1600619114 modified "2023-09-27" @default.
• W1600619114 title "Relative contribution of the Na+/Ca2+ exchanger, mitochondria and endoplasmic reticulum in the regulation of cytosolic Ca2+ and catecholamine secretion of bovine adrenal chromaffin cells" @default.
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• W1600619114 doi "https://doi.org/10.1046/j.1471-4159.2001.00055.x" @default.
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