FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1600644808> ?p ?o ?g. }

• W1600644808 abstract "Summary. Pegylated interferon (IFN), the basis for chronic hepatitis C virus (HCV) treatment, causes depression in 30–40% of patients. The potential for cytokine mRNA patterns from baseline into early treatment to associate with the onset of treatment‐induced depression (TID) was examined. Depression was measured by the Beck Depression Inventory at baseline and weeks 2, 4, 8 and 12 of treatment ( n = 38). At baseline and weeks 2 and 4, peripheral blood mononuclear cell (PMBC, n = 28), isolated ex vivo , were examined for tumour neurosis factor (TNF)‐alpha, interleukin (IL)‐1beta and IL‐10 mRNA expression. In patients that developed treatment‐induced depression, pro‐inflammatory TNF‐alpha mRNA levels from baseline into week 4 of therapy remained constant (1.1‐fold increase); whereas IL‐1beta transcripts decreased 3.5 fold. However, corresponding TNF‐alpha (3‐fold, P < 0.05) and IL‐1beta (7.5‐fold) transcript expression diminished to a greater extent in the absence of TID. Changes in TNF‐alpha mRNA values correlated to the average change in BDI scores over the 12 weeks ( r = 0.56, P < 0.05). Concomitantly, anti‐inflammatory IL‐10 transcript levels decreased in (TID), relative to increased expression in the absence of TID ( P < 0.05). The potential influence of IL‐10 was observed upon calculation of individual pro‐ verses anti‐inflammatory mRNA ratios. Stable in the presence of depression, TNF‐alpha/IL‐10 and IL‐1beta/IL‐10 mRNA ratios declined significantly over time in its absence ( P < 0.05). This study suggests that in chronic HCV infection, upon pegylated IFN administration persistent pro‐inflammatory cytokine MRNA expression associates with TID. In contrast, therapeutic activation of mechanisms that decrease pro‐inflammatory immunity may protect against depression during therapy." @default.
• W1600644808 created "2016-06-24" @default.
• W1600644808 creator A5001939748 @default.
• W1600644808 creator A5035654219 @default.
• W1600644808 creator A5043777943 @default.
• W1600644808 creator A5048201114 @default.
• W1600644808 creator A5064766413 @default.
• W1600644808 creator A5067215566 @default.
• W1600644808 date "2010-12-08" @default.
• W1600644808 modified "2023-09-25" @default.
• W1600644808 title "Persistent pro‐inflammatory cytokines following the initiation of pegylated IFN therapy in hepatitis C infection is associated with treatment‐induced depression" @default.
• W1600644808 cites W1591586719 @default.
• W1600644808 cites W1969022059 @default.
• W1600644808 cites W1973685382 @default.
• W1600644808 cites W1984760175 @default.
• W1600644808 cites W1995596015 @default.
• W1600644808 cites W1996850319 @default.
• W1600644808 cites W1998976706 @default.
• W1600644808 cites W2002267508 @default.
• W1600644808 cites W2004252684 @default.
• W1600644808 cites W2015419490 @default.
• W1600644808 cites W2024038063 @default.
• W1600644808 cites W2025438730 @default.
• W1600644808 cites W2027545702 @default.
• W1600644808 cites W2038333667 @default.
• W1600644808 cites W2044508901 @default.
• W1600644808 cites W2047987784 @default.
• W1600644808 cites W2048431959 @default.
• W1600644808 cites W2058720438 @default.
• W1600644808 cites W2061604734 @default.
• W1600644808 cites W2063139961 @default.
• W1600644808 cites W2063579231 @default.
• W1600644808 cites W2063715840 @default.
• W1600644808 cites W2066049515 @default.
• W1600644808 cites W2082240834 @default.
• W1600644808 cites W2084681612 @default.
• W1600644808 cites W2085486223 @default.
• W1600644808 cites W2091975706 @default.
• W1600644808 cites W2093052211 @default.
• W1600644808 cites W2093850082 @default.
• W1600644808 cites W2094404268 @default.
• W1600644808 cites W2096036729 @default.
• W1600644808 cites W2119526257 @default.
• W1600644808 cites W2120987567 @default.
• W1600644808 cites W2122246785 @default.
• W1600644808 cites W2127533867 @default.
• W1600644808 cites W2127685726 @default.
• W1600644808 cites W2130069961 @default.
• W1600644808 cites W2141249273 @default.
• W1600644808 cites W2151059850 @default.
• W1600644808 cites W2159568556 @default.
• W1600644808 cites W2159847907 @default.
• W1600644808 cites W2163817149 @default.
• W1600644808 cites W2317554121 @default.
• W1600644808 cites W4248373454 @default.
• W1600644808 doi "https://doi.org/10.1111/j.1365-2893.2010.01408.x" @default.
• W1600644808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21143344" @default.
• W1600644808 hasPublicationYear "2010" @default.
• W1600644808 type Work @default.
• W1600644808 sameAs 1600644808 @default.
• W1600644808 citedByCount "19" @default.
• W1600644808 countsByYear W16006448082012 @default.
• W1600644808 countsByYear W16006448082013 @default.
• W1600644808 countsByYear W16006448082014 @default.
• W1600644808 countsByYear W16006448082015 @default.
• W1600644808 countsByYear W16006448082016 @default.
• W1600644808 countsByYear W16006448082017 @default.
• W1600644808 countsByYear W16006448082019 @default.
• W1600644808 countsByYear W16006448082020 @default.
• W1600644808 countsByYear W16006448082021 @default.
• W1600644808 crossrefType "journal-article" @default.
• W1600644808 hasAuthorship W1600644808A5001939748 @default.
• W1600644808 hasAuthorship W1600644808A5035654219 @default.
• W1600644808 hasAuthorship W1600644808A5043777943 @default.
• W1600644808 hasAuthorship W1600644808A5048201114 @default.
• W1600644808 hasAuthorship W1600644808A5064766413 @default.
• W1600644808 hasAuthorship W1600644808A5067215566 @default.
• W1600644808 hasConcept C118552586 @default.
• W1600644808 hasConcept C126322002 @default.
• W1600644808 hasConcept C134018914 @default.
• W1600644808 hasConcept C137061746 @default.
• W1600644808 hasConcept C139719470 @default.
• W1600644808 hasConcept C150903083 @default.
• W1600644808 hasConcept C162324750 @default.
• W1600644808 hasConcept C17991360 @default.
• W1600644808 hasConcept C202751555 @default.
• W1600644808 hasConcept C203014093 @default.
• W1600644808 hasConcept C207001950 @default.
• W1600644808 hasConcept C2522874641 @default.
• W1600644808 hasConcept C2776461080 @default.
• W1600644808 hasConcept C2776867660 @default.
• W1600644808 hasConcept C2778690821 @default.
• W1600644808 hasConcept C2779631380 @default.
• W1600644808 hasConcept C2780040827 @default.
• W1600644808 hasConcept C3020491458 @default.
• W1600644808 hasConcept C55493867 @default.
• W1600644808 hasConcept C558461103 @default.
• W1600644808 hasConcept C71924100 @default.
• W1600644808 hasConcept C86803240 @default.
• W1600644808 hasConcept C90924648 @default.

• next