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• W1600724186 abstract "The IVOMEC SR® (sustained release) bolus is an osmotically driven drug delivery system designed for the long-term delivery to cattle of the antiparasitic drug, ivermectin. The bolus is administered orally by means of a balling gun and the weight of the bolus keeps it in the reticulum/rumen for the lifetime of the animal. The onset of delivery is immediate upon placement in the rumen and effective doses are delivered within the first week following administration. The steady-state delivery rate of approximately 12 mg/day of ivermectin is maintained for a period of approximately 135 days, after which, delivery ceases quickly. This duration is sufficient to provide season-long delivery of drug to grazing cattle." @default.
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• W1600724186 date "1997-07-01" @default.
• W1600724186 modified "2023-10-14" @default.
• W1600724186 title "The in vitro and in vivo performance of an osmotically controlled delivery system — IVOMEC SR®1®Registered Trademark of Merck and Co.1 bolus" @default.
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• W1600724186 doi "https://doi.org/10.1016/s0168-3659(96)01610-0" @default.
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