FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1600857098> ?p ?o ?g. }

• W1600857098 endingPage "86" @default.
• W1600857098 startingPage "79" @default.
• W1600857098 abstract "Acetaminophen (paracetamol) is a commonly and widely used analgesic and antipyretic agent, but at high dose it leads to undesirable side effects, such as hepatotoxicity. The study investigate the hepatoprotective effect of ethanolic leaf extract of Vernonia amygdalina and ethanolic leaf extract of Azadirachta indica against acetaminophen-induced hepatotoxicity in Sprague -Dawley male albino rats. Male albino rats were randomly divided into six groups each consisting of five albino rats. Group A rats served as the normal control and were given water daily for a period of 14 days. Hepatotoxicity was induced in-vivo to all animals of Groups B, C, D, E, and F orally by administering 2g /kg body weight of paracetamol once a day for a period of 14 days. Group C, D, E and F were orally administered silymarin (100 mg/kg B.W), Vitamin C (100 mg/kg B.W), ethanolic leaf extract of V. amygdalina (300 mg/kg B.W) and A. indica (300 mg/kg B.W) respectively daily for a period of 14 days. Group B animals served as the paracetamol control and they were not treated. The result of this study shows that animals treated with silymarin, V. amygdalina and A. indica extracts significantly (P<0.05) have reduced WBC count compared to paracetamol control group. HGB, RBC and HCT values in all the groups administered with silymarin, Vitamin C, V. amygdalina and A. indica extracts were significantly (P<0.05) increased when compared to the paracetamol- intoxicated animals without treatment. Oral administration of acetaminophen caused marked liver damage as noted by the significant increased (P<0.05) in activities of plasma AST, ALT, ALP and GGT as well as the level of cholesterol, triglyceride and a reduction in plasma total protein. The drug also resulted to a significant increase (P<0.05) in liver MDA content, decrease in liver GSH content, decrease in SOD and CAT activities. Treatment with silymarin, Vitamin C, V. amygdalina and A. indica extracts showed effective hepatoprotective effect as evidence in the decrease in the plasma levels of liver biomarker enzymes and reduction in oxidative stress parameters. Histopathological evaluation of the liver architecture also revealed that all the treated animals have reduced the incidence of paracetamol- induced liver lesions." @default.
• W1600857098 created "2016-06-24" @default.
• W1600857098 creator A5013180302 @default.
• W1600857098 creator A5016210239 @default.
• W1600857098 creator A5073090155 @default.
• W1600857098 creator A5088397602 @default.
• W1600857098 date "2015-07-06" @default.
• W1600857098 modified "2023-09-23" @default.
• W1600857098 title "Hepatoprotective Effect of Ethanolic Leaf Extract of Vernonia amygdalina and Azadirachta indica against Acetaminophen-Induced Hepatotoxicity inSprague-Dawley Male Albino Rats" @default.
• W1600857098 cites W1482264334 @default.
• W1600857098 cites W1520696705 @default.
• W1600857098 cites W1523638942 @default.
• W1600857098 cites W1585941096 @default.
• W1600857098 cites W1591008116 @default.
• W1600857098 cites W1609961433 @default.
• W1600857098 cites W1904705252 @default.
• W1600857098 cites W1973760627 @default.
• W1600857098 cites W1976411950 @default.
• W1600857098 cites W1986798142 @default.
• W1600857098 cites W2009397778 @default.
• W1600857098 cites W2012635889 @default.
• W1600857098 cites W2015814720 @default.
• W1600857098 cites W2029360775 @default.
• W1600857098 cites W2045981977 @default.
• W1600857098 cites W2049532327 @default.
• W1600857098 cites W2050733923 @default.
• W1600857098 cites W2054545767 @default.
• W1600857098 cites W2058581984 @default.
• W1600857098 cites W2061763404 @default.
• W1600857098 cites W2063854658 @default.
• W1600857098 cites W2065403387 @default.
• W1600857098 cites W2065565632 @default.
• W1600857098 cites W2066723064 @default.
• W1600857098 cites W2076519801 @default.
• W1600857098 cites W2087815467 @default.
• W1600857098 cites W2089945888 @default.
• W1600857098 cites W2096795975 @default.
• W1600857098 cites W2128536806 @default.
• W1600857098 cites W2137890026 @default.
• W1600857098 cites W2138162004 @default.
• W1600857098 cites W2144934601 @default.
• W1600857098 cites W2146250885 @default.
• W1600857098 cites W2153940277 @default.
• W1600857098 cites W2154332459 @default.
• W1600857098 cites W2164176210 @default.
• W1600857098 cites W2168480601 @default.
• W1600857098 cites W2169958072 @default.
• W1600857098 cites W2182119585 @default.
• W1600857098 cites W2188743612 @default.
• W1600857098 cites W2300575681 @default.
• W1600857098 cites W2332991947 @default.
• W1600857098 cites W2460220878 @default.
• W1600857098 cites W2483838079 @default.
• W1600857098 cites W26788231 @default.
• W1600857098 cites W2113063030 @default.
• W1600857098 cites W2163662599 @default.
• W1600857098 cites W2189598143 @default.
• W1600857098 doi "https://doi.org/10.12691/ajps-3-3-5" @default.
• W1600857098 hasPublicationYear "2015" @default.
• W1600857098 type Work @default.
• W1600857098 sameAs 1600857098 @default.
• W1600857098 citedByCount "3" @default.
• W1600857098 countsByYear W16008570982017 @default.
• W1600857098 countsByYear W16008570982018 @default.
• W1600857098 countsByYear W16008570982019 @default.
• W1600857098 crossrefType "journal-article" @default.
• W1600857098 hasAuthorship W1600857098A5013180302 @default.
• W1600857098 hasAuthorship W1600857098A5016210239 @default.
• W1600857098 hasAuthorship W1600857098A5073090155 @default.
• W1600857098 hasAuthorship W1600857098A5088397602 @default.
• W1600857098 hasConcept C185592680 @default.
• W1600857098 hasConcept C2777056448 @default.
• W1600857098 hasConcept C2777594791 @default.
• W1600857098 hasConcept C2778722691 @default.
• W1600857098 hasConcept C2779252780 @default.
• W1600857098 hasConcept C2779703632 @default.
• W1600857098 hasConcept C2780820201 @default.
• W1600857098 hasConcept C2781035296 @default.
• W1600857098 hasConcept C556039675 @default.
• W1600857098 hasConcept C71924100 @default.
• W1600857098 hasConcept C98274493 @default.
• W1600857098 hasConceptScore W1600857098C185592680 @default.
• W1600857098 hasConceptScore W1600857098C2777056448 @default.
• W1600857098 hasConceptScore W1600857098C2777594791 @default.
• W1600857098 hasConceptScore W1600857098C2778722691 @default.
• W1600857098 hasConceptScore W1600857098C2779252780 @default.
• W1600857098 hasConceptScore W1600857098C2779703632 @default.
• W1600857098 hasConceptScore W1600857098C2780820201 @default.
• W1600857098 hasConceptScore W1600857098C2781035296 @default.
• W1600857098 hasConceptScore W1600857098C556039675 @default.
• W1600857098 hasConceptScore W1600857098C71924100 @default.
• W1600857098 hasConceptScore W1600857098C98274493 @default.
• W1600857098 hasIssue "3" @default.
• W1600857098 hasLocation W16008570981 @default.
• W1600857098 hasOpenAccess W1600857098 @default.
• W1600857098 hasPrimaryLocation W16008570981 @default.
• W1600857098 hasRelatedWork W1583047820 @default.
• W1600857098 hasRelatedWork W1584013717 @default.

• next