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- W1600873838 abstract "Susceptibility to tuberculosis is multifactorial. Theimportance of host genetic factors on the susceptibilityor resistance to tuberculosis has been emphasized bymany workers. Host genetic factors such as humanleucocyte antigens (HLA) and non-HLA genes that areassociated with the susceptibility to tuberculosis willserve as genetic markers to predispose or predeterminethe development of the disease. Such markers may beuseful to understand the immune mechanism of susceptibilityor resistance to tuberculosis. Association ofvarious HLA and non-HLA genes with susceptibilityto tuberculosis in various ethnic population has beenestablished. HLA studies carried out in the Asianregion, especially in India, revealed the association ofHLA-DR2 and -DQ1 antigens with the susceptibilityto pulmonary TB. Further, studies on DNA typingexplored the association of DRB1 *1501 and *1502(DR2 subtypes) in north Indian and DRB1 *1501, DRB1*0601 (DQ1 subtype) and DPB1 *02 (DP2 subtype) insouth Indian population. Various studies on non-classicalmajor histocompatibility complex (MHC) genes andnon-MHC/non-HLA gene polymorphisms such as transporterassociated with antigen processing (TAP), tumournecrosis factor a and b (TNF a and b), mannose bindinglectin (MBL), vitamin D receptor (VDR) (BsmI,ApaI, TaqI and FokI polymorphisms), Interleukin-1receptor antagonist (IL-1RA) and natural resistanceassociated macrophage protein-1 (NRAMP-1) genesrevealed the association of TAP2 gene variant alongwith HLA–DR2 and functional mutant homozygotes(FMHs) of MBL with the susceptibility to pulmonaryTB. The polymorphic BsmI, ApaI, TaqI and FokI genevariants of VDR showed differential susceptibility andresistance with male and female subjects. These studiessuggest that multicandidate genes are associated withthe susceptibility to pulmonary tuberculosis in India." @default.
- W1600873838 created "2016-06-24" @default.
- W1600873838 creator A5047318755 @default.
- W1600873838 date "2004-01-01" @default.
- W1600873838 modified "2023-09-23" @default.
- W1600873838 title "Host genetics and tuberculosis susceptibility" @default.
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