Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601039432> ?p ?o ?g. }
- W1601039432 abstract "Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder in which autoantibodies are directed against muscle receptors. MG causes fluctuating muscle weakness, which often involves droopy eyelids, swallowing difficulties and generalized muscle fatigue in the neck and proximal muscles of the legs and arms. The prevalence of MG is two times higher in women than in men. Age is also a prevailing factor, affecting women whom are 20-30 years of age, whereas men are 60-80 years old (Osserman and Genkins 1971). The annual incidence of MG has been reported to be about 3-4 cases per million and the overall prevalence about 60 cases per million; however, higher rates have recently been suggested, indicating a potential prevalence as high as 20 per 100 000 persons. (Kalb, Matell et al. 2002; Phillips 2003). The most common form of MG is associated with antibodies against the nicotinic acetylcholine receptor (AChR), present in about 85% of patients with generalised MG (Vincent and Newsom Davis 1980). In 2001 antibodies against the muscle specific tyrosine kinase (MuSK) were identified in about 40-70% of patients without detectable AChR antibodies (Hoch, McConville et al. 2001). Furthermore, in approximately 5-10% of patients with the generalized disease no antibodies are present in the serum, but these cases all have the features of an autoimmune course. This chapter deals with the clinical phenotype, neurophysiology and consequences at the neuromuscular junction of the autoimmune attack associated with MG as well as treatment options. The focus will be on MuSK antibody seropositive (MuSK+) MG in human patients and the experimental murine model of MuSK+ MG." @default.
- W1601039432 created "2016-06-24" @default.
- W1601039432 creator A5064459555 @default.
- W1601039432 date "2011-11-14" @default.
- W1601039432 modified "2023-09-30" @default.
- W1601039432 title "Myasthenia Gravis: New Insights into the Effect of MuSK Antibodies and Acetylcholinesterase Inhibitors" @default.
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