FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601070312> ?p ?o ?g. }

• W1601070312 endingPage "3246" @default.
• W1601070312 startingPage "3237" @default.
• W1601070312 abstract "Abstract Recent studies of murine models of mucosal inflammation suggest that, whereas some kinds of bacterial microflora are inducers of disease, others, known as probiotics, prevent disease. In the present study, we analyzed the regulatory cytokine and cell response to probiotic (VSL#3) administration in the context of the Th1 T cell colitis induced by trinitrobenzene sulfonic acid treatment of SJL/J mice. Daily administration of probiotics for 3 wk to mice during a remission period between a first and second course of colitis induced by trinitrobenzene sulfonic acid, resulted in a milder form of recurrent colitis than observed in mice administered PBS during this same period. This protective effect was attributable to effects on the lamina propria mononuclear cell (LPMC) population, because it could be transferred by LPMC from probiotic-treated mice to naive mice. Probiotic administration was associated with an early increase in the production of IL-10 and an increased number of regulatory CD4+ T cells bearing surface TGF-β in the form of latency-associated protein (LAP) (LAP+ T cells). The latter were dependent on the IL-10 production because administration of anti-IL-10R mAb blocked their appearance. Finally, the LAP+ T cells were essential to the protective effect of probiotics because administration of anti-IL-10R or anti-TGF-β at the initiation of recurrent colitis induction or depletion of LAP+ T cells from LPMC abolished the latter’s capacity to transfer protection to naive recipients. These studies show that probiotic (VSL#3) administration during a remission period ameliorates the severity of recurrent colitis by inducing an immunoregulatory response involving TGF-β-bearing regulatory cells." @default.
• W1601070312 created "2016-06-24" @default.
• W1601070312 creator A5053370481 @default.
• W1601070312 creator A5069892594 @default.
• W1601070312 creator A5074404662 @default.
• W1601070312 creator A5077194201 @default.
• W1601070312 creator A5083001869 @default.
• W1601070312 date "2005-03-15" @default.
• W1601070312 modified "2023-10-17" @default.
• W1601070312 title "Probiotics Ameliorate Recurrent Th1-Mediated Murine Colitis by Inducing IL-10 and IL-10-Dependent TGF-β-Bearing Regulatory Cells" @default.
• W1601070312 cites W1504236935 @default.
• W1601070312 cites W1619959770 @default.
• W1601070312 cites W1898102248 @default.
• W1601070312 cites W1964521586 @default.
• W1601070312 cites W1971737706 @default.
• W1601070312 cites W1972408068 @default.
• W1601070312 cites W1987811803 @default.
• W1601070312 cites W1988830582 @default.
• W1601070312 cites W1992025079 @default.
• W1601070312 cites W2017443683 @default.
• W1601070312 cites W2018091449 @default.
• W1601070312 cites W2036042297 @default.
• W1601070312 cites W2041696905 @default.
• W1601070312 cites W2075702769 @default.
• W1601070312 cites W2090210288 @default.
• W1601070312 cites W2090631845 @default.
• W1601070312 cites W2098101166 @default.
• W1601070312 cites W2102267843 @default.
• W1601070312 cites W2105270270 @default.
• W1601070312 cites W2114164427 @default.
• W1601070312 cites W2114424280 @default.
• W1601070312 cites W2117616114 @default.
• W1601070312 cites W2120010406 @default.
• W1601070312 cites W2132516980 @default.
• W1601070312 cites W2137451902 @default.
• W1601070312 cites W2139759128 @default.
• W1601070312 cites W2142071589 @default.
• W1601070312 cites W2148859286 @default.
• W1601070312 cites W2148947634 @default.
• W1601070312 cites W4292198229 @default.
• W1601070312 doi "https://doi.org/10.4049/jimmunol.174.6.3237" @default.
• W1601070312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15749854" @default.
• W1601070312 hasPublicationYear "2005" @default.
• W1601070312 type Work @default.
• W1601070312 sameAs 1601070312 @default.
• W1601070312 citedByCount "489" @default.
• W1601070312 countsByYear W16010703122012 @default.
• W1601070312 countsByYear W16010703122013 @default.
• W1601070312 countsByYear W16010703122014 @default.
• W1601070312 countsByYear W16010703122015 @default.
• W1601070312 countsByYear W16010703122016 @default.
• W1601070312 countsByYear W16010703122017 @default.
• W1601070312 countsByYear W16010703122018 @default.
• W1601070312 countsByYear W16010703122019 @default.
• W1601070312 countsByYear W16010703122020 @default.
• W1601070312 countsByYear W16010703122021 @default.
• W1601070312 countsByYear W16010703122022 @default.
• W1601070312 countsByYear W16010703122023 @default.
• W1601070312 crossrefType "journal-article" @default.
• W1601070312 hasAuthorship W1601070312A5053370481 @default.
• W1601070312 hasAuthorship W1601070312A5069892594 @default.
• W1601070312 hasAuthorship W1601070312A5074404662 @default.
• W1601070312 hasAuthorship W1601070312A5077194201 @default.
• W1601070312 hasAuthorship W1601070312A5083001869 @default.
• W1601070312 hasBestOaLocation W16010703121 @default.
• W1601070312 hasConcept C137061746 @default.
• W1601070312 hasConcept C142724271 @default.
• W1601070312 hasConcept C187316574 @default.
• W1601070312 hasConcept C202751555 @default.
• W1601070312 hasConcept C203014093 @default.
• W1601070312 hasConcept C2775862500 @default.
• W1601070312 hasConcept C2776090121 @default.
• W1601070312 hasConcept C2777310793 @default.
• W1601070312 hasConcept C2778296632 @default.
• W1601070312 hasConcept C2778690821 @default.
• W1601070312 hasConcept C2779727006 @default.
• W1601070312 hasConcept C2780255968 @default.
• W1601070312 hasConcept C2908647359 @default.
• W1601070312 hasConcept C523546767 @default.
• W1601070312 hasConcept C529295009 @default.
• W1601070312 hasConcept C54355233 @default.
• W1601070312 hasConcept C55493867 @default.
• W1601070312 hasConcept C71924100 @default.
• W1601070312 hasConcept C79484868 @default.
• W1601070312 hasConcept C86803240 @default.
• W1601070312 hasConcept C8891405 @default.
• W1601070312 hasConcept C90375314 @default.
• W1601070312 hasConcept C99454951 @default.
• W1601070312 hasConceptScore W1601070312C137061746 @default.
• W1601070312 hasConceptScore W1601070312C142724271 @default.
• W1601070312 hasConceptScore W1601070312C187316574 @default.
• W1601070312 hasConceptScore W1601070312C202751555 @default.
• W1601070312 hasConceptScore W1601070312C203014093 @default.
• W1601070312 hasConceptScore W1601070312C2775862500 @default.
• W1601070312 hasConceptScore W1601070312C2776090121 @default.
• W1601070312 hasConceptScore W1601070312C2777310793 @default.
• W1601070312 hasConceptScore W1601070312C2778296632 @default.
• W1601070312 hasConceptScore W1601070312C2778690821 @default.

• next