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- W1601071785 abstract "The rapid emerge of antimicrobial resistance due to ESBL has a significant impact in public health. In the last 24 years, the study of extendedspectrum- β-lactamases (ESBL) has created great interest. This has been documented by publications from all continents and more than 30 countries, and the extent of this problem is a public health concern. ESBLs produced by Gram negative bacilli are enzymes that confer resistance to penicillins, cepaholosporins and aztreonam, but not to carbapenems or cephamycins, and are usually inhibited by clavulanic acid. Most of the ESBLs are derived from TEM-1, TEM-2 and SHV-1, and differ from their progenitors by only a few amino-acids. Thus, their phylogeny is close. ESBLs are usually found in E. coli, Klebsiella sp, and Proteus mirabilis. However, there are some ESBL phylogenetic branches that differ from TEM and SHV, such as CTX-M, OXA carbapenemases, VIM and IMP metalo-β-lactamases, typically found in P. aeruginosa, Serratia sp and Enterobacter sp. ESBL production by different clinical pathogens imply an important clinical problem in nosocomial patients due to medical, therapeutic and economical impact. ESBL detection techniques include simple tests as well as complex detection system involving molecular genotyping. This review discusses the most prevalent ESBLs and their epidemiological and clinical impact. Also, it presents tools and strategies for ESBL detection and molecular tracking at the nosocomial level." @default.
- W1601071785 created "2016-06-24" @default.
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- W1601071785 date "2011-10-06" @default.
- W1601071785 modified "2023-10-12" @default.
- W1601071785 title "Emergencia de la resistencia antibiótica debida a las β-lactamasas de espectro extendido (BLEE): detección, impacto clínico y epidemiología" @default.
- W1601071785 hasPublicationYear "2011" @default.
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