Matches in SemOpenAlex for { <https://semopenalex.org/work/W16010913> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W16010913 endingPage "1091" @default.
- W16010913 startingPage "1088" @default.
- W16010913 abstract "Therapeutic options for metastatic renal cell carcinoma (mRCC) have been evolving rapidly, with the approval of a variety of effective molecular targeted agents. With increasing choices of treatment modalities that may potentially improve survival, it is of great clinical benefit to be able to predict the clinical outcome of mRCC patients treated with molecular targeted agents. In addition, predictors of severe adverse events are warranted since those molecular targeted agents present a toxicity profile that is very different from that of conventional chemotherapeutic agents. Their use requires knowledge of a large number of possible adverse events. Although validation of previous criteria, such as the Motzer criteria, is important, a further implementation of RCC molecular biology knowledge would be ideal for finding a new predictive marker in this new age of molecular targeted therapies. The most prominent biomarker is vascular endothelial-derived growth factor (VEGF). Those patients who presented low serum VEGF showed prolonged progression-free survival when treated with sunitinib. Genetic markers such as single nucleotide polymorphisms (SNPs) are continuously being validated as markers, predicting molecular targeted therapy response as well as severe adverse events. The identification of biomarkers that predict response or severe adverse events from molecular targeted agents will aid in patient selection and guide therapy development." @default.
- W16010913 created "2016-06-24" @default.
- W16010913 creator A5017359886 @default.
- W16010913 creator A5086644570 @default.
- W16010913 date "2011-07-01" @default.
- W16010913 modified "2023-09-26" @default.
- W16010913 title "Biomarkers of response to molecular targeted therapy in renal cell carcinoma" @default.
- W16010913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21772092" @default.
- W16010913 hasPublicationYear "2011" @default.
- W16010913 type Work @default.
- W16010913 sameAs 16010913 @default.
- W16010913 citedByCount "0" @default.
- W16010913 crossrefType "journal-article" @default.
- W16010913 hasAuthorship W16010913A5017359886 @default.
- W16010913 hasAuthorship W16010913A5086644570 @default.
- W16010913 hasConcept C121608353 @default.
- W16010913 hasConcept C126322002 @default.
- W16010913 hasConcept C143998085 @default.
- W16010913 hasConcept C197934379 @default.
- W16010913 hasConcept C2777472916 @default.
- W16010913 hasConcept C2779490328 @default.
- W16010913 hasConcept C2781197716 @default.
- W16010913 hasConcept C2781230642 @default.
- W16010913 hasConcept C3019646584 @default.
- W16010913 hasConcept C55493867 @default.
- W16010913 hasConcept C60644358 @default.
- W16010913 hasConcept C71924100 @default.
- W16010913 hasConcept C86803240 @default.
- W16010913 hasConceptScore W16010913C121608353 @default.
- W16010913 hasConceptScore W16010913C126322002 @default.
- W16010913 hasConceptScore W16010913C143998085 @default.
- W16010913 hasConceptScore W16010913C197934379 @default.
- W16010913 hasConceptScore W16010913C2777472916 @default.
- W16010913 hasConceptScore W16010913C2779490328 @default.
- W16010913 hasConceptScore W16010913C2781197716 @default.
- W16010913 hasConceptScore W16010913C2781230642 @default.
- W16010913 hasConceptScore W16010913C3019646584 @default.
- W16010913 hasConceptScore W16010913C55493867 @default.
- W16010913 hasConceptScore W16010913C60644358 @default.
- W16010913 hasConceptScore W16010913C71924100 @default.
- W16010913 hasConceptScore W16010913C86803240 @default.
- W16010913 hasIssue "7" @default.
- W16010913 hasLocation W160109131 @default.
- W16010913 hasLocation W160109132 @default.
- W16010913 hasOpenAccess W16010913 @default.
- W16010913 hasPrimaryLocation W160109131 @default.
- W16010913 hasRelatedWork W1163432324 @default.
- W16010913 hasRelatedWork W1456399444 @default.
- W16010913 hasRelatedWork W1563190138 @default.
- W16010913 hasRelatedWork W1642002521 @default.
- W16010913 hasRelatedWork W1979457557 @default.
- W16010913 hasRelatedWork W1980407360 @default.
- W16010913 hasRelatedWork W2015456845 @default.
- W16010913 hasRelatedWork W2068750741 @default.
- W16010913 hasRelatedWork W2211817100 @default.
- W16010913 hasRelatedWork W2212205525 @default.
- W16010913 hasRelatedWork W2260197997 @default.
- W16010913 hasRelatedWork W2369409544 @default.
- W16010913 hasRelatedWork W2397202023 @default.
- W16010913 hasRelatedWork W2568241591 @default.
- W16010913 hasRelatedWork W2590493027 @default.
- W16010913 hasRelatedWork W2806905249 @default.
- W16010913 hasRelatedWork W2987915428 @default.
- W16010913 hasRelatedWork W3030971988 @default.
- W16010913 hasRelatedWork W636660849 @default.
- W16010913 hasRelatedWork W2977626320 @default.
- W16010913 hasVolume "38" @default.
- W16010913 isParatext "false" @default.
- W16010913 isRetracted "false" @default.
- W16010913 magId "16010913" @default.
- W16010913 workType "article" @default.