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W1601166150 endingPage "31" @default.
W1601166150 startingPage "1" @default.
W1601166150 abstract "Abstract Growth factor (GF) receptors are extracellular receptors which, when bound by growth factors, initiate intracellular signaling for promoting cellular proliferation, survival, and differentiation. The amount of signaling is generally controlled by both the levels of growth factor and the levels of GF receptors present in the cell, particularly at the cell surface. This review will focus on the mechanisms of endocytosis and postendocytic trafficking that serve to control the levels of GF receptors. The classical experimental system used to investigate these processes is the endocytosis of GF receptors that possess intrinsic tyrosine kinase activity, known as receptor tyrosine kinases (RTKs). We will use the prototypical RTK, epidermal growth factor receptor (EGFR), as the model GF receptor in this discussion since much of the data leading to the current understanding of GF receptor endocytosis was generated using this receptor.Growth factor (GF) receptors are extracellular receptors which, when bound by growth factors, initiate intracellular signaling for promoting cellular proliferation, survival, and differentiation. The amount of signaling is generally controlled by both the levels of growth factor and the levels of GF receptors present in the cell, particularly at the cell surface. This review will focus on the mechanisms of endocytosis and postendocytic trafficking that serve to control the levels of GF receptors. The classical experimental system used to investigate these processes is the endocytosis of GF receptors that possess intrinsic tyrosine kinase activity, known as receptor tyrosine kinases (RTKs). We will use the prototypical RTK, epidermal growth factor receptor (EGFR), as the model GF receptor in this discussion since much of the data leading to the current understanding of GF receptor endocytosis was generated using this receptor." @default.
W1601166150 created "2016-06-24" @default.
W1601166150 creator A5052583319 @default.
W1601166150 creator A5073726679 @default.
W1601166150 date "2010-04-15" @default.
W1601166150 modified "2023-10-10" @default.
W1601166150 title "Growth Factors: Protein Processing, Endocytosis, and Intracellular Sorting" @default.
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