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• W1601321166 abstract "Evidence from human and animal studies has highlighted the sensitivity of the developing fetus to environmental insults, such as maternal undernutrition, during gestation. These nutritional perturbations to the intrauterine milieu may engender a legacy of deleterious health consequences in adulthood. This thesis presents a series of studies which test the `mis-match‘ fetal programming theory; that is, whether a nutritionally poor diet prenatally interacts with a nutritionally excessive diet postnatally to overtly increase risk factors for adult disease. The effect of a maternal global energy restriction is contrasted against a maternal specific protein restriction, each fed during either early or late gestation. Adult offspring were subsequently exposed to an obesogenic environment (elevated feed with increased lipid content whilst restricting physical activity). Offspring metabolic flexibility and competence were assessed through routine blood samples throughout postnatal life and at 7, 18 and 24 months of age by glucose (GTT) and insulin (ITT) tolerance tests and body composition by dual energy x-ray absorptiometry. In general males appeared more susceptible to developmental programming than females at a number of timepoints. Furthermore, an increased first-phase or incremental area-under-the-insulin-response curve was observed in 1) offspring following maternal protein restriction in early gestation at 7 and 24 months of age, despite maternal protein restriction in late gestation significantly reducing birthweight and 2) in offspring exposed to maternal energy restriction during late gestation at 24 months of age in response to a GTT. Since, in both groups, the response of all offspring to an ITT (from a euglycemic baseline) was similar, infers that developmental programming in sheep followed by nutritional excess is first revealed as affecting either the pancreas (~insulin hypersecretion) or the liver (hepatic insulin resistance, reduced first-pass insulin metabolism). The studies illustrate the importance of habitual consumption of an `optimal’ balanced diet through gestation on postnatal health, especially in light of the current obesity epidemic." @default.
• W1601321166 created "2016-06-24" @default.
• W1601321166 creator A5010262474 @default.
• W1601321166 date "2011-07-22" @default.
• W1601321166 modified "2023-09-27" @default.
• W1601321166 title "The interaction between maternal nutrient restriction and postnatal nutrient excess in an ovine model" @default.
• W1601321166 cites W108802658 @default.
• W1601321166 cites W116808744 @default.
• W1601321166 cites W1483436245 @default.
• W1601321166 cites W1503180342 @default.
• W1601321166 cites W1515251958 @default.
• W1601321166 cites W1526313338 @default.
• W1601321166 cites W1530587475 @default.
• W1601321166 cites W1543840311 @default.
• W1601321166 cites W1549364582 @default.
• W1601321166 cites W1569940121 @default.
• W1601321166 cites W1577920001 @default.
• W1601321166 cites W1584337354 @default.
• W1601321166 cites W1591327376 @default.
• W1601321166 cites W1592327102 @default.
• W1601321166 cites W1592830383 @default.
• W1601321166 cites W1602240110 @default.
• W1601321166 cites W1693014831 @default.
• W1601321166 cites W176361816 @default.
• W1601321166 cites W1821797507 @default.
• W1601321166 cites W1901968456 @default.
• W1601321166 cites W1927942771 @default.
• W1601321166 cites W1932533342 @default.
• W1601321166 cites W1941626479 @default.
• W1601321166 cites W1965996330 @default.
• W1601321166 cites W1967064280 @default.
• W1601321166 cites W1967348945 @default.
• W1601321166 cites W1967480974 @default.
• W1601321166 cites W1968082263 @default.
• W1601321166 cites W1969076348 @default.
• W1601321166 cites W1969235931 @default.
• W1601321166 cites W1969655939 @default.
• W1601321166 cites W1969822520 @default.
• W1601321166 cites W1970489683 @default.
• W1601321166 cites W1970673437 @default.
• W1601321166 cites W1971011572 @default.
• W1601321166 cites W1971922927 @default.
• W1601321166 cites W1972432934 @default.
• W1601321166 cites W1972589639 @default.
• W1601321166 cites W1973217053 @default.
• W1601321166 cites W1973708085 @default.
• W1601321166 cites W1977411338 @default.
• W1601321166 cites W1978167945 @default.
• W1601321166 cites W1978450788 @default.
• W1601321166 cites W1978932360 @default.
• W1601321166 cites W1979445839 @default.
• W1601321166 cites W1979667855 @default.
• W1601321166 cites W1982712185 @default.
• W1601321166 cites W1982863473 @default.
• W1601321166 cites W1983680508 @default.
• W1601321166 cites W1984806127 @default.
• W1601321166 cites W1985342348 @default.
• W1601321166 cites W1985533068 @default.
• W1601321166 cites W1987493742 @default.
• W1601321166 cites W1987865047 @default.
• W1601321166 cites W1988406724 @default.
• W1601321166 cites W1988933948 @default.
• W1601321166 cites W1989662858 @default.
• W1601321166 cites W1990133684 @default.
• W1601321166 cites W1990786422 @default.
• W1601321166 cites W1992276646 @default.
• W1601321166 cites W1992794071 @default.
• W1601321166 cites W1993921006 @default.
• W1601321166 cites W1994164408 @default.
• W1601321166 cites W1995180097 @default.
• W1601321166 cites W1995776140 @default.
• W1601321166 cites W1997080611 @default.
• W1601321166 cites W1998223245 @default.
• W1601321166 cites W1998970086 @default.
• W1601321166 cites W1999266159 @default.
• W1601321166 cites W2000792567 @default.
• W1601321166 cites W2000954385 @default.
• W1601321166 cites W2001883083 @default.
• W1601321166 cites W2003032553 @default.
• W1601321166 cites W2004969093 @default.
• W1601321166 cites W2005802710 @default.
• W1601321166 cites W2006828160 @default.
• W1601321166 cites W2008621322 @default.
• W1601321166 cites W2009216259 @default.
• W1601321166 cites W2009396016 @default.
• W1601321166 cites W2010632937 @default.
• W1601321166 cites W2010992180 @default.
• W1601321166 cites W2011361446 @default.
• W1601321166 cites W2011880080 @default.
• W1601321166 cites W2012037560 @default.
• W1601321166 cites W2013456794 @default.
• W1601321166 cites W2014565407 @default.
• W1601321166 cites W2014671368 @default.
• W1601321166 cites W2015007412 @default.
• W1601321166 cites W2017507345 @default.
• W1601321166 cites W2019158187 @default.
• W1601321166 cites W2019314939 @default.
• W1601321166 cites W2019552448 @default.
• W1601321166 cites W2020089988 @default.
• W1601321166 cites W2020267609 @default.

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