FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601321489> ?p ?o ?g. }

• W1601321489 endingPage "e1052353" @default.
• W1601321489 startingPage "e1052353" @default.
• W1601321489 abstract "In this study we characterize a new mechanism by which Natural Killer (NK) cells may amplify their recruitment to tumors. We show that NK cells, upon interaction with melanoma cells, can release a chemotactic form of High Mobility Group Box-1 (HMGB1) protein capable of attracting additional activated NK cells. We first demonstrate that the engagement of different activating NK cell receptors, including those mainly involved in tumor cell recognition can induce the active release of HMGB1. Then we show that during NK-mediated tumor cell killing two HMGB1 forms are released, each displaying a specific electrophoretic mobility possibly corresponding to a different redox status. By the comparison of normal and perforin-defective NK cells (which are unable to kill target cells) we demonstrate that, in NK/melanoma cell co-cultures, NK cells specifically release an HMGB1 form that acts as chemoattractant, while dying tumor cells passively release a non-chemotactic HMGB1. Finally, we show that Receptor for Advanced Glycation End products is expressed by NK cells and mediates HMGB1-induced NK cell chemotaxis. Proteomic analysis of NK cells exposed to recombinant HMGB1 revealed that this molecule, besides inducing immediate chemotaxis, also promotes changes in the expression of proteins involved in the regulation of the cytoskeletal network. Importantly, these modifications could be associated with an increased motility of NK cells. Thus, our findings allow the definition of a previously unidentified mechanism used by NK cells to amplify their response to tumors, and provide additional clues for the emerging role of HMGB1 in immunomodulation and tumor immunity." @default.
• W1601321489 created "2016-06-24" @default.
• W1601321489 creator A5005363449 @default.
• W1601321489 creator A5006396046 @default.
• W1601321489 creator A5014012949 @default.
• W1601321489 creator A5020843731 @default.
• W1601321489 creator A5023093018 @default.
• W1601321489 creator A5027162539 @default.
• W1601321489 creator A5029764194 @default.
• W1601321489 creator A5034149467 @default.
• W1601321489 creator A5035849763 @default.
• W1601321489 creator A5048786304 @default.
• W1601321489 creator A5051475554 @default.
• W1601321489 creator A5055337483 @default.
• W1601321489 creator A5068187248 @default.
• W1601321489 creator A5073875192 @default.
• W1601321489 creator A5080732030 @default.
• W1601321489 creator A5084633521 @default.
• W1601321489 date "2015-05-29" @default.
• W1601321489 modified "2023-09-27" @default.
• W1601321489 title "Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment" @default.
• W1601321489 cites W1541265927 @default.
• W1601321489 cites W1560838147 @default.
• W1601321489 cites W1581623404 @default.
• W1601321489 cites W1594965720 @default.
• W1601321489 cites W1672954108 @default.
• W1601321489 cites W1964596126 @default.
• W1601321489 cites W1969305254 @default.
• W1601321489 cites W1969422685 @default.
• W1601321489 cites W1970534551 @default.
• W1601321489 cites W1978586979 @default.
• W1601321489 cites W1985042500 @default.
• W1601321489 cites W1996032846 @default.
• W1601321489 cites W1997849135 @default.
• W1601321489 cites W2001477058 @default.
• W1601321489 cites W2005203470 @default.
• W1601321489 cites W2017618441 @default.
• W1601321489 cites W2019804037 @default.
• W1601321489 cites W2029524107 @default.
• W1601321489 cites W2041220742 @default.
• W1601321489 cites W2043969722 @default.
• W1601321489 cites W2044451873 @default.
• W1601321489 cites W2046056818 @default.
• W1601321489 cites W2046290067 @default.
• W1601321489 cites W2052094075 @default.
• W1601321489 cites W2054298924 @default.
• W1601321489 cites W2056887320 @default.
• W1601321489 cites W2057936936 @default.
• W1601321489 cites W2064544100 @default.
• W1601321489 cites W2064871989 @default.
• W1601321489 cites W2076831072 @default.
• W1601321489 cites W2077226382 @default.
• W1601321489 cites W2080820947 @default.
• W1601321489 cites W2082272174 @default.
• W1601321489 cites W2084623259 @default.
• W1601321489 cites W2093424661 @default.
• W1601321489 cites W2094700934 @default.
• W1601321489 cites W2095239046 @default.
• W1601321489 cites W2097383206 @default.
• W1601321489 cites W2098981101 @default.
• W1601321489 cites W2102515794 @default.
• W1601321489 cites W2106949373 @default.
• W1601321489 cites W2112400160 @default.
• W1601321489 cites W2119014922 @default.
• W1601321489 cites W2120344463 @default.
• W1601321489 cites W2122541507 @default.
• W1601321489 cites W2130401210 @default.
• W1601321489 cites W2132280604 @default.
• W1601321489 cites W2132812582 @default.
• W1601321489 cites W2141436376 @default.
• W1601321489 cites W2141438911 @default.
• W1601321489 cites W2142607055 @default.
• W1601321489 cites W2143460699 @default.
• W1601321489 cites W2146313292 @default.
• W1601321489 cites W2150132523 @default.
• W1601321489 cites W2152273129 @default.
• W1601321489 cites W2156985714 @default.
• W1601321489 cites W2160712716 @default.
• W1601321489 cites W2161193578 @default.
• W1601321489 cites W2162119603 @default.
• W1601321489 cites W2163614144 @default.
• W1601321489 cites W2166495164 @default.
• W1601321489 cites W2169290104 @default.
• W1601321489 cites W2172030715 @default.
• W1601321489 doi "https://doi.org/10.1080/2162402x.2015.1052353" @default.
• W1601321489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4635845" @default.
• W1601321489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26587323" @default.
• W1601321489 hasPublicationYear "2015" @default.
• W1601321489 type Work @default.
• W1601321489 sameAs 1601321489 @default.
• W1601321489 citedByCount "31" @default.
• W1601321489 countsByYear W16013214892016 @default.
• W1601321489 countsByYear W16013214892017 @default.
• W1601321489 countsByYear W16013214892018 @default.
• W1601321489 countsByYear W16013214892019 @default.
• W1601321489 countsByYear W16013214892020 @default.
• W1601321489 countsByYear W16013214892021 @default.
• W1601321489 countsByYear W16013214892022 @default.

• next