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- W1601346220 abstract "The origin of desacetylcephalosporin C in cephalosporin C fermentation broths was investigated. Esterase activity was detected in cell-free extracts of Cephalosporium acremonium , but these extracts failed to deesterify cephalosporin C. When cephalosporin C was added to sterile and inoculated fermentation media, the antibiotic decayed at nearly identical rates. The formation of desacetylcephalosporin C during the fermentation was measured by quantitative chromatography and by the incorporation of valine- 1 - 14 C into the molecule. The rate constants obtained from the results of these experiments were equivalent to those for the decay of cephalosporin C in sterile and inoculated media. The data demonstrate that desacetylcephalosporin C is produced by nonenzymatic hydrolysis of cephalosporin C." @default.
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- W1601346220 date "1968-07-01" @default.
- W1601346220 modified "2023-09-24" @default.
- W1601346220 title "Formation of Desacetylcephalosporin C in Cephalosporin C Fermentation" @default.
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- W1601346220 doi "https://doi.org/10.1128/am.16.7.1011-1014.1968" @default.
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