Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601354410> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1601354410 endingPage "514" @default.
- W1601354410 startingPage "507" @default.
- W1601354410 abstract "Abstract A series of mouse monoclonal anti-CD4 preparations was characterized for the ability to recognize overlapping epitopes on CD4 and to inhibit HIV/simian immunodeficiency virus (SIV) syncytium formation. Based on this characterization, mAb able to recognize CD4 epitopes overlapping the HIV binding site were selected and used to immunize nonhuman primates to elicit the production of specific anti-Id antibodies. Five baboons and five rhesus monkeys were immunized with either individual or a cocktail consisting of several monoclonal anti-CD4 preparations. All the nonhuman primates produced specific anti-Id that recognized either private or cross-reactive Id depending on the monoclonal anti-CD4 used to generate the anti-Id response. Inhibition assays were performed to ascertain the ability of: 1) soluble CD4 to inhibit the Id-anti-Id reaction and 2) the various anti-Id to inhibit the CD4-monoclonal anti-CD4 reaction. These studies demonstrated that some of the anti-Id recognized a cross-reactive Id that was associated with the Ag-combining site. In addition, some of the anti-Id weakly recognized SIV gp120 by Western blot analysis. These studies may be useful in designing experiments that may lead to a better understanding of the CD4-HIV gp120 interaction and to the production of Id and/or anti-Id reagents that might be used to manipulate this virus-receptor interaction." @default.
- W1601354410 created "2016-06-24" @default.
- W1601354410 creator A5023595056 @default.
- W1601354410 creator A5028456537 @default.
- W1601354410 creator A5029370799 @default.
- W1601354410 creator A5060270535 @default.
- W1601354410 creator A5063986694 @default.
- W1601354410 date "1991-01-15" @default.
- W1601354410 modified "2023-10-04" @default.
- W1601354410 title "Anti-idiotypic antibody response to monoclonal anti-CD4 preparations in nonhuman primate species." @default.
- W1601354410 doi "https://doi.org/10.4049/jimmunol.146.2.507" @default.
- W1601354410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1702802" @default.
- W1601354410 hasPublicationYear "1991" @default.
- W1601354410 type Work @default.
- W1601354410 sameAs 1601354410 @default.
- W1601354410 citedByCount "18" @default.
- W1601354410 countsByYear W16013544102015 @default.
- W1601354410 crossrefType "journal-article" @default.
- W1601354410 hasAuthorship W1601354410A5023595056 @default.
- W1601354410 hasAuthorship W1601354410A5028456537 @default.
- W1601354410 hasAuthorship W1601354410A5029370799 @default.
- W1601354410 hasAuthorship W1601354410A5060270535 @default.
- W1601354410 hasAuthorship W1601354410A5063986694 @default.
- W1601354410 hasBestOaLocation W16013544101 @default.
- W1601354410 hasConcept C153911025 @default.
- W1601354410 hasConcept C159047783 @default.
- W1601354410 hasConcept C159654299 @default.
- W1601354410 hasConcept C163864487 @default.
- W1601354410 hasConcept C195616568 @default.
- W1601354410 hasConcept C203014093 @default.
- W1601354410 hasConcept C2522874641 @default.
- W1601354410 hasConcept C2777995582 @default.
- W1601354410 hasConcept C40479148 @default.
- W1601354410 hasConcept C542903549 @default.
- W1601354410 hasConcept C86803240 @default.
- W1601354410 hasConceptScore W1601354410C153911025 @default.
- W1601354410 hasConceptScore W1601354410C159047783 @default.
- W1601354410 hasConceptScore W1601354410C159654299 @default.
- W1601354410 hasConceptScore W1601354410C163864487 @default.
- W1601354410 hasConceptScore W1601354410C195616568 @default.
- W1601354410 hasConceptScore W1601354410C203014093 @default.
- W1601354410 hasConceptScore W1601354410C2522874641 @default.
- W1601354410 hasConceptScore W1601354410C2777995582 @default.
- W1601354410 hasConceptScore W1601354410C40479148 @default.
- W1601354410 hasConceptScore W1601354410C542903549 @default.
- W1601354410 hasConceptScore W1601354410C86803240 @default.
- W1601354410 hasIssue "2" @default.
- W1601354410 hasLocation W16013544101 @default.
- W1601354410 hasLocation W16013544102 @default.
- W1601354410 hasOpenAccess W1601354410 @default.
- W1601354410 hasPrimaryLocation W16013544101 @default.
- W1601354410 hasRelatedWork W1992624427 @default.
- W1601354410 hasRelatedWork W1996802981 @default.
- W1601354410 hasRelatedWork W2062904381 @default.
- W1601354410 hasRelatedWork W2091594406 @default.
- W1601354410 hasRelatedWork W2101049085 @default.
- W1601354410 hasRelatedWork W2106670663 @default.
- W1601354410 hasRelatedWork W2126011181 @default.
- W1601354410 hasRelatedWork W2419969028 @default.
- W1601354410 hasRelatedWork W4252441337 @default.
- W1601354410 hasRelatedWork W2024154056 @default.
- W1601354410 hasVolume "146" @default.
- W1601354410 isParatext "false" @default.
- W1601354410 isRetracted "false" @default.
- W1601354410 magId "1601354410" @default.
- W1601354410 workType "article" @default.