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• W1601385148 abstract "Phosphorylation at multiple sites within the N‐terminus of p53 promotes its dissociation from hdm2/mdm2 and stimulates its transcriptional regulatory potential. The large phosphoinositide 3‐kinase‐like kinases ataxia telangiectasia mutated gene product and the ataxia telangectasia and RAD‐3‐related kinase promote phosphorylation of human p53 at Ser15 and Ser20, and are required for the activation of p53 following DNA damage. DNA‐dependent protein kinase (DNA‐PK) is another large phosphoinositide 3‐kinase‐like kinase with the potential to phosphorylate p53 at Ser15, and has been proposed to enhance phosphorylation of these sites in vivo . Moreover, recent studies support a role for DNA‐PK in the regulation of p53‐mediated apoptosis. We have shown previously that colocalization of p53 and DNA‐PK to structured single‐stranded DNA dramatically enhances the potential for p53 phosphorylation by DNA‐PK. We report here the identification of p53 phosphorylation at two novel sites for DNA‐PK, Thr18 and Ser9. Colocalization of p53 and DNA‐PK on structured DNA was required for efficient phosphorylation of p53 at multiple sites, while specific recognition of Ser9 and Thr18 appeared to be dependent upon additional determinants of p53 beyond the N‐terminal 65 amino acids. Our results suggest a role for DNA‐PK in the modulation of p53 activity resultant from the convergence of p53 and DNA‐PK on structured DNA." @default.
• W1601385148 created "2016-06-24" @default.
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• W1601385148 date "2004-08-24" @default.
• W1601385148 modified "2023-10-17" @default.
• W1601385148 title "Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18" @default.
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• W1601385148 doi "https://doi.org/10.1111/j.1432-1033.2004.04319.x" @default.
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