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• W160146944 abstract "Neuritic (senile) plaques and neurofibrillary tangles (NFT) represent the principal structural alterations of neurons in presenile and senile dementia of the Alzheimer type (Alzheimer’s disease). These two types of lesions are also found in much smaller numbers and in restricted topographical distribution in the brains of many neurologically normal individuals after the seventh decade. Tangles, plaques and other structural changes found in Alzheimer brain tissue (amyloid angiopathy of cerebral and meningeal vessels, granulovacuolar degeneration of hippocampal neurons, lipofuscin deposition in neurons and glia) are, therefore, qualitatively indistinguishable from the lesions that accompany normal brain aging but are quantitatively much increased in AD. Neurofibrillary tangles (NFT) are large, non-membrane-bound cytoplasmic masses of abnormal fibers found within the perikarya of neurons in hippocampus, amygdala, cerebral cortex and certain deep gray nuclear structures. Numerous electron microscopic studies have concluded that the vast majority of fibers in these tangles have the appearance of tightly adherent pairs of helically wound, intermediate-sized (10 nm) filaments, referred to as paired helical filaments (PHF), and having a maximum width of about 20 nm and a half-periodicity of roughly 80 nm (1,2,3). Many of the abnormal neurites (both axonal terminals and dendrites) making up the periphery of the senile plaque contain PHF (4)." @default.
• W160146944 created "2016-06-24" @default.
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• W160146944 date "1987-01-01" @default.
• W160146944 modified "2023-09-27" @default.
• W160146944 title "Intraneuronal and Extracellular Filaments in the Pathogenesis of Alzheimer’s Disease" @default.
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• W160146944 doi "https://doi.org/10.1007/978-1-4613-1657-2_8" @default.
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