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- W1601471013 endingPage "584" @default.
- W1601471013 startingPage "574" @default.
- W1601471013 abstract "The LKB1 tumour suppressor is a serine/threonine kinase that functions as master regulator of cell growth, metabolism, survival and polarity. LKB1 is frequently mutated in human cancers and research spanning the last two decades have begun decoding the cellular pathways deregulated following LKB1 inactivation. This work has led to the identification of vulnerabilities present in LKB1-deficient tumour cells. Pre-clinical studies have now identified therapeutic strategies targeting this subset of tumours that promise to benefit this large patient population harbouring LKB1 mutations. Here, we review the current efforts that are underway to translate pre-clinical discovery of therapeutic strategies targeting LKB1 mutant cancers into clinical practice." @default.
- W1601471013 created "2016-06-24" @default.
- W1601471013 creator A5076473304 @default.
- W1601471013 creator A5079324651 @default.
- W1601471013 date "2015-07-21" @default.
- W1601471013 modified "2023-10-09" @default.
- W1601471013 title "Targeting LKB1 in cancer – exposing and exploiting vulnerabilities" @default.
- W1601471013 cites W1523693806 @default.
- W1601471013 cites W1619256199 @default.
- W1601471013 cites W1965626427 @default.
- W1601471013 cites W1966706887 @default.
- W1601471013 cites W1967199837 @default.
- W1601471013 cites W1967580058 @default.
- W1601471013 cites W1969705513 @default.
- W1601471013 cites W1974183354 @default.
- W1601471013 cites W1974228534 @default.
- W1601471013 cites W1974883167 @default.
- W1601471013 cites W1975755652 @default.
- W1601471013 cites W1976323469 @default.
- W1601471013 cites W1978528142 @default.
- W1601471013 cites W1983762572 @default.
- W1601471013 cites W1984877787 @default.
- W1601471013 cites W1989368804 @default.
- W1601471013 cites W1990278643 @default.
- W1601471013 cites W1991473393 @default.
- W1601471013 cites W1992257057 @default.
- W1601471013 cites W1992893449 @default.
- W1601471013 cites W1993267911 @default.
- W1601471013 cites W1995069275 @default.
- W1601471013 cites W1996612168 @default.
- W1601471013 cites W1997224005 @default.
- W1601471013 cites W1998206026 @default.
- W1601471013 cites W1999731922 @default.
- W1601471013 cites W2001568034 @default.
- W1601471013 cites W2001999652 @default.
- W1601471013 cites W2004329237 @default.
- W1601471013 cites W2009785633 @default.
- W1601471013 cites W2010916968 @default.
- W1601471013 cites W2013149980 @default.
- W1601471013 cites W2014782980 @default.
- W1601471013 cites W2016752484 @default.
- W1601471013 cites W2017166332 @default.
- W1601471013 cites W2025935112 @default.
- W1601471013 cites W2026967508 @default.
- W1601471013 cites W2028701135 @default.
- W1601471013 cites W2029938976 @default.
- W1601471013 cites W2030031350 @default.
- W1601471013 cites W2030629791 @default.
- W1601471013 cites W2031541159 @default.
- W1601471013 cites W2032607892 @default.
- W1601471013 cites W2033768919 @default.
- W1601471013 cites W2035521247 @default.
- W1601471013 cites W2038014733 @default.
- W1601471013 cites W2038712067 @default.
- W1601471013 cites W2040022677 @default.
- W1601471013 cites W2042523021 @default.
- W1601471013 cites W2043398720 @default.
- W1601471013 cites W2044874695 @default.
- W1601471013 cites W2045048651 @default.
- W1601471013 cites W2045129123 @default.
- W1601471013 cites W2049279804 @default.
- W1601471013 cites W2050052799 @default.
- W1601471013 cites W2050790870 @default.
- W1601471013 cites W2053627244 @default.
- W1601471013 cites W2055309955 @default.
- W1601471013 cites W2059825898 @default.
- W1601471013 cites W2064475159 @default.
- W1601471013 cites W2065260669 @default.
- W1601471013 cites W2065432613 @default.
- W1601471013 cites W2067979493 @default.
- W1601471013 cites W2069815371 @default.
- W1601471013 cites W2070151086 @default.
- W1601471013 cites W2070910260 @default.
- W1601471013 cites W2078236973 @default.
- W1601471013 cites W2079580613 @default.
- W1601471013 cites W2080107084 @default.
- W1601471013 cites W2081920342 @default.
- W1601471013 cites W2082108947 @default.
- W1601471013 cites W2083855694 @default.
- W1601471013 cites W2084202927 @default.
- W1601471013 cites W2084821546 @default.
- W1601471013 cites W2086589626 @default.
- W1601471013 cites W2087656113 @default.
- W1601471013 cites W2087750317 @default.
- W1601471013 cites W2087851161 @default.
- W1601471013 cites W2088469990 @default.
- W1601471013 cites W2089376520 @default.
- W1601471013 cites W2090165847 @default.
- W1601471013 cites W2094207365 @default.
- W1601471013 cites W2094638529 @default.
- W1601471013 cites W2095282719 @default.
- W1601471013 cites W2095454212 @default.
- W1601471013 cites W2098167876 @default.
- W1601471013 cites W2098947405 @default.
- W1601471013 cites W2101228747 @default.
- W1601471013 cites W2101882540 @default.
- W1601471013 cites W2102891343 @default.
- W1601471013 cites W2103445331 @default.