Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601474975> ?p ?o ?g. }
- W1601474975 endingPage "1522" @default.
- W1601474975 startingPage "1511" @default.
- W1601474975 abstract "Phosphorylase kinase (PhK) is a large hexadecameric enzyme consisting of four copies of four subunits: (alphabetagammadelta)4. An intrinsic calmodulin (CaM, the delta subunit) binds directly to the gamma protein kinase chain. The interaction site of CaM on gamma has been localized to a C-terminal extension of the kinase domain. Two 25-mer peptides derived from this region, PhK5 and PhK13, were identified previously as potential CaM-binding sites. Complex formation between Ca2+/CaM with these two peptides was characterized using analytical gel filtration and NMR methods. NMR chemical shift perturbation studies showed that while PhK5 forms a robust complex with Ca2+/CaM, no interactions with PhK13 were observed. 15N relaxation characteristics of Ca2+/CaM and Ca2+/CaM/PhK5 complexes were compared with the experimentally determined structures of several Ca2+/CaM/peptide complexes. Good fits were observed between Ca2+/CaM/PhK5 and three structures: Ca2+/CaM complexes with peptides from endothelial nitric oxide synthase, with smooth muscle myosin light chain kinase and CaM kinase I. We conclude that the PhK5 site is likely to have a direct role in Ca2+-regulated control of PhK activity through the formation of a classical 'compact' CaM complex." @default.
- W1601474975 created "2016-06-24" @default.
- W1601474975 creator A5021285723 @default.
- W1601474975 creator A5029246908 @default.
- W1601474975 creator A5044816611 @default.
- W1601474975 date "2005-03-03" @default.
- W1601474975 modified "2023-10-14" @default.
- W1601474975 title "Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide" @default.
- W1601474975 cites W1479897117 @default.
- W1601474975 cites W1485888367 @default.
- W1601474975 cites W150287726 @default.
- W1601474975 cites W1532995690 @default.
- W1601474975 cites W1585062682 @default.
- W1601474975 cites W1607298303 @default.
- W1601474975 cites W1767701883 @default.
- W1601474975 cites W1774689153 @default.
- W1601474975 cites W1967305385 @default.
- W1601474975 cites W1979901011 @default.
- W1601474975 cites W1985629904 @default.
- W1601474975 cites W1987159249 @default.
- W1601474975 cites W1990402608 @default.
- W1601474975 cites W2000948557 @default.
- W1601474975 cites W2008067524 @default.
- W1601474975 cites W2012088552 @default.
- W1601474975 cites W2013067273 @default.
- W1601474975 cites W2018802747 @default.
- W1601474975 cites W2020397809 @default.
- W1601474975 cites W2023196077 @default.
- W1601474975 cites W2025305309 @default.
- W1601474975 cites W2030205108 @default.
- W1601474975 cites W2030490793 @default.
- W1601474975 cites W2031811477 @default.
- W1601474975 cites W2042917934 @default.
- W1601474975 cites W2044970538 @default.
- W1601474975 cites W2052366943 @default.
- W1601474975 cites W2055957948 @default.
- W1601474975 cites W2057347947 @default.
- W1601474975 cites W2062517296 @default.
- W1601474975 cites W2066636450 @default.
- W1601474975 cites W2068668512 @default.
- W1601474975 cites W2089765713 @default.
- W1601474975 cites W2125330937 @default.
- W1601474975 cites W2135783131 @default.
- W1601474975 cites W2142175567 @default.
- W1601474975 cites W2142497607 @default.
- W1601474975 cites W2164655870 @default.
- W1601474975 cites W2169364535 @default.
- W1601474975 cites W2172712627 @default.
- W1601474975 cites W2181409396 @default.
- W1601474975 cites W23570572 @default.
- W1601474975 cites W4299595455 @default.
- W1601474975 doi "https://doi.org/10.1111/j.1742-4658.2005.04591.x" @default.
- W1601474975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15752366" @default.
- W1601474975 hasPublicationYear "2005" @default.
- W1601474975 type Work @default.
- W1601474975 sameAs 1601474975 @default.
- W1601474975 citedByCount "9" @default.
- W1601474975 countsByYear W16014749752012 @default.
- W1601474975 countsByYear W16014749752015 @default.
- W1601474975 countsByYear W16014749752016 @default.
- W1601474975 countsByYear W16014749752019 @default.
- W1601474975 crossrefType "journal-article" @default.
- W1601474975 hasAuthorship W1601474975A5021285723 @default.
- W1601474975 hasAuthorship W1601474975A5029246908 @default.
- W1601474975 hasAuthorship W1601474975A5044816611 @default.
- W1601474975 hasBestOaLocation W16014749751 @default.
- W1601474975 hasConcept C104292427 @default.
- W1601474975 hasConcept C104317684 @default.
- W1601474975 hasConcept C12554922 @default.
- W1601474975 hasConcept C181199279 @default.
- W1601474975 hasConcept C184235292 @default.
- W1601474975 hasConcept C185592680 @default.
- W1601474975 hasConcept C195147555 @default.
- W1601474975 hasConcept C204779464 @default.
- W1601474975 hasConcept C2776277561 @default.
- W1601474975 hasConcept C2777468819 @default.
- W1601474975 hasConcept C2779281246 @default.
- W1601474975 hasConcept C29688787 @default.
- W1601474975 hasConcept C515207424 @default.
- W1601474975 hasConcept C55493867 @default.
- W1601474975 hasConcept C6997183 @default.
- W1601474975 hasConcept C71240020 @default.
- W1601474975 hasConcept C8010536 @default.
- W1601474975 hasConcept C8035138 @default.
- W1601474975 hasConcept C86803240 @default.
- W1601474975 hasConcept C97029542 @default.
- W1601474975 hasConceptScore W1601474975C104292427 @default.
- W1601474975 hasConceptScore W1601474975C104317684 @default.
- W1601474975 hasConceptScore W1601474975C12554922 @default.
- W1601474975 hasConceptScore W1601474975C181199279 @default.
- W1601474975 hasConceptScore W1601474975C184235292 @default.
- W1601474975 hasConceptScore W1601474975C185592680 @default.
- W1601474975 hasConceptScore W1601474975C195147555 @default.
- W1601474975 hasConceptScore W1601474975C204779464 @default.
- W1601474975 hasConceptScore W1601474975C2776277561 @default.
- W1601474975 hasConceptScore W1601474975C2777468819 @default.
- W1601474975 hasConceptScore W1601474975C2779281246 @default.
- W1601474975 hasConceptScore W1601474975C29688787 @default.