FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601476460> ?p ?o ?g. }

• W1601476460 endingPage "3818" @default.
• W1601476460 startingPage "3812" @default.
• W1601476460 abstract "Triggering receptor expressed on myeloid cells (TREM)-1 is a cell surface molecule expressed on neutrophils and monocytes implicated in the propagation of the inflammatory response. To further characterize the function of this molecule in different phases of the immune response, we examined TREM-1 in the context of host defense against microbial pathogens. In primary human monocytes TREM-1 activation did not trigger innate antimicrobial pathways directed against intracellular <i>Mycobacterium tuberculosis</i>, and only minimally improved phagocytosis. However, activation of TREM-1 on monocytes did drive robust production of proinflammatory chemokines such as macrophage inflammatory protein-1α and IL-8. Engagement of TREM-1 in combination with microbial ligands that activate Toll-like receptors also synergistically increased production of the proinflammatory cytokines TNF-α and GM-CSF, while inhibiting production of IL-10, an anti-inflammatory cytokine. Expression of TREM-1 was up-regulated in response to TLR activation, an effect further enhanced by GM-CSF and TNF-α but inhibited by IL-10. Functionally, primary monocytes differentiated into immature dendritic cells following activation through TREM-1, evidenced by higher expression of CD1a, CD86, and MHC class II molecules. These cells had an improved ability to elicit T cell proliferation and production of IFN-γ. Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges." @default.
• W1601476460 created "2016-06-24" @default.
• W1601476460 creator A5009942708 @default.
• W1601476460 creator A5025833826 @default.
• W1601476460 creator A5034774800 @default.
• W1601476460 creator A5048521691 @default.
• W1601476460 creator A5051544508 @default.
• W1601476460 creator A5052850535 @default.
• W1601476460 creator A5055691289 @default.
• W1601476460 date "2003-04-01" @default.
• W1601476460 modified "2023-10-10" @default.
• W1601476460 title "A Role for Triggering Receptor Expressed on Myeloid Cells-1 in Host Defense During the Early-Induced and Adaptive Phases of the Immune Response" @default.
• W1601476460 cites W1483162601 @default.
• W1601476460 cites W1643888758 @default.
• W1601476460 cites W1655860314 @default.
• W1601476460 cites W1661544713 @default.
• W1601476460 cites W1794218861 @default.
• W1601476460 cites W1827266985 @default.
• W1601476460 cites W1930598094 @default.
• W1601476460 cites W2016381907 @default.
• W1601476460 cites W2028092080 @default.
• W1601476460 cites W2040838085 @default.
• W1601476460 cites W2046747192 @default.
• W1601476460 cites W2062811432 @default.
• W1601476460 cites W2110101961 @default.
• W1601476460 cites W2114829829 @default.
• W1601476460 cites W2115993724 @default.
• W1601476460 cites W2116495710 @default.
• W1601476460 cites W2130649175 @default.
• W1601476460 cites W2131761283 @default.
• W1601476460 cites W2145078103 @default.
• W1601476460 cites W2149698238 @default.
• W1601476460 cites W2153736795 @default.
• W1601476460 cites W2155229523 @default.
• W1601476460 cites W2157569416 @default.
• W1601476460 cites W2161273761 @default.
• W1601476460 cites W97158386 @default.
• W1601476460 doi "https://doi.org/10.4049/jimmunol.170.7.3812" @default.
• W1601476460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12646648" @default.
• W1601476460 hasPublicationYear "2003" @default.
• W1601476460 type Work @default.
• W1601476460 sameAs 1601476460 @default.
• W1601476460 citedByCount "302" @default.
• W1601476460 countsByYear W16014764602012 @default.
• W1601476460 countsByYear W16014764602013 @default.
• W1601476460 countsByYear W16014764602014 @default.
• W1601476460 countsByYear W16014764602015 @default.
• W1601476460 countsByYear W16014764602016 @default.
• W1601476460 countsByYear W16014764602017 @default.
• W1601476460 countsByYear W16014764602018 @default.
• W1601476460 countsByYear W16014764602019 @default.
• W1601476460 countsByYear W16014764602020 @default.
• W1601476460 countsByYear W16014764602021 @default.
• W1601476460 countsByYear W16014764602022 @default.
• W1601476460 countsByYear W16014764602023 @default.
• W1601476460 crossrefType "journal-article" @default.
• W1601476460 hasAuthorship W1601476460A5009942708 @default.
• W1601476460 hasAuthorship W1601476460A5025833826 @default.
• W1601476460 hasAuthorship W1601476460A5034774800 @default.
• W1601476460 hasAuthorship W1601476460A5048521691 @default.
• W1601476460 hasAuthorship W1601476460A5051544508 @default.
• W1601476460 hasAuthorship W1601476460A5052850535 @default.
• W1601476460 hasAuthorship W1601476460A5055691289 @default.
• W1601476460 hasBestOaLocation W16014764601 @default.
• W1601476460 hasConcept C13373296 @default.
• W1601476460 hasConcept C136449434 @default.
• W1601476460 hasConcept C164027704 @default.
• W1601476460 hasConcept C170493617 @default.
• W1601476460 hasConcept C193419808 @default.
• W1601476460 hasConcept C203014093 @default.
• W1601476460 hasConcept C2776090121 @default.
• W1601476460 hasConcept C2776914184 @default.
• W1601476460 hasConcept C2778690821 @default.
• W1601476460 hasConcept C2781101188 @default.
• W1601476460 hasConcept C55493867 @default.
• W1601476460 hasConcept C86803240 @default.
• W1601476460 hasConcept C8891405 @default.
• W1601476460 hasConcept C95444343 @default.
• W1601476460 hasConceptScore W1601476460C13373296 @default.
• W1601476460 hasConceptScore W1601476460C136449434 @default.
• W1601476460 hasConceptScore W1601476460C164027704 @default.
• W1601476460 hasConceptScore W1601476460C170493617 @default.
• W1601476460 hasConceptScore W1601476460C193419808 @default.
• W1601476460 hasConceptScore W1601476460C203014093 @default.
• W1601476460 hasConceptScore W1601476460C2776090121 @default.
• W1601476460 hasConceptScore W1601476460C2776914184 @default.
• W1601476460 hasConceptScore W1601476460C2778690821 @default.
• W1601476460 hasConceptScore W1601476460C2781101188 @default.
• W1601476460 hasConceptScore W1601476460C55493867 @default.
• W1601476460 hasConceptScore W1601476460C86803240 @default.
• W1601476460 hasConceptScore W1601476460C8891405 @default.
• W1601476460 hasConceptScore W1601476460C95444343 @default.
• W1601476460 hasIssue "7" @default.
• W1601476460 hasLocation W16014764601 @default.
• W1601476460 hasLocation W16014764602 @default.
• W1601476460 hasOpenAccess W1601476460 @default.
• W1601476460 hasPrimaryLocation W16014764601 @default.
• W1601476460 hasRelatedWork W1536533081 @default.

• next