Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601557881> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1601557881 endingPage "9253" @default.
- W1601557881 startingPage "9250" @default.
- W1601557881 abstract "Previous studies have demonstrated an imbalance in placental levels of the human choriogonadotropin (hCG) alpha and beta subunits. Free alpha subunit was present in first trimester placentae, and the imbalance was accentuated as gestation approached parturition. Two sets of experiments were performed to assess the control on production levels of each subunit. Synthesis of the alpha and beta subunits was assessed by labeling the nascent chains of polysomes derived from first trimester placenta. The products of these reactions were immunoprecipitated with subunit-specific antisera and the labeled subunits were quantitated; the ratio of alpha to beta subunit synthesized was 1.7. To examine whether this imbalanced synthesis reflected differences in the amount of subunit mRNAs, or differing mRNA translational efficiencies, the ratio of the steady state levels of these mRNAs was also determined. Total first trimester placental RNA was hydrolyzed with alkali, 5'-end-labeled with 32P, and hybridized in DNA excess to cloned alpha and beta cDNAs. These experiments demonstrated the presence of twice as much hCG-alpha mRNA as hCG-beta mRNA. In term placenta, the amounts of excess alpha subunit are greater than at first trimester; the ratio of alpha to beta mRNAs in term RNA was about 12:1. Thus, the subunit mRNA levels are independently regulated and their imbalance accounts for differences in the quantities of alpha and beta subunits seen in placental tissue." @default.
- W1601557881 created "2016-06-24" @default.
- W1601557881 creator A5043054491 @default.
- W1601557881 creator A5068525117 @default.
- W1601557881 creator A5084902610 @default.
- W1601557881 date "1983-08-01" @default.
- W1601557881 modified "2023-09-27" @default.
- W1601557881 title "Imbalanced synthesis of human choriogonadotropin alpha and beta subunits reflects the steady state levels of the corresponding mRNAs." @default.
- W1601557881 cites W1497345935 @default.
- W1601557881 cites W1503363627 @default.
- W1601557881 cites W1532528754 @default.
- W1601557881 cites W1551862023 @default.
- W1601557881 cites W1554020743 @default.
- W1601557881 cites W1602608751 @default.
- W1601557881 cites W1627508921 @default.
- W1601557881 cites W1821604348 @default.
- W1601557881 cites W2002869303 @default.
- W1601557881 cites W2003333228 @default.
- W1601557881 cites W2010451894 @default.
- W1601557881 cites W2015880687 @default.
- W1601557881 cites W2022768773 @default.
- W1601557881 cites W2027424239 @default.
- W1601557881 cites W2035633375 @default.
- W1601557881 cites W2052723514 @default.
- W1601557881 cites W2057560047 @default.
- W1601557881 cites W2064291396 @default.
- W1601557881 cites W2075335963 @default.
- W1601557881 cites W2079809058 @default.
- W1601557881 cites W2083761061 @default.
- W1601557881 cites W2095922270 @default.
- W1601557881 cites W2102129370 @default.
- W1601557881 cites W2120338020 @default.
- W1601557881 cites W2125164984 @default.
- W1601557881 cites W4231152632 @default.
- W1601557881 doi "https://doi.org/10.1016/s0021-9258(17)44659-x" @default.
- W1601557881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6192128" @default.
- W1601557881 hasPublicationYear "1983" @default.
- W1601557881 type Work @default.
- W1601557881 sameAs 1601557881 @default.
- W1601557881 citedByCount "40" @default.
- W1601557881 countsByYear W16015578812023 @default.
- W1601557881 crossrefType "journal-article" @default.
- W1601557881 hasAuthorship W1601557881A5043054491 @default.
- W1601557881 hasAuthorship W1601557881A5068525117 @default.
- W1601557881 hasAuthorship W1601557881A5084902610 @default.
- W1601557881 hasBestOaLocation W16015578811 @default.
- W1601557881 hasConcept C12554922 @default.
- W1601557881 hasConcept C147789679 @default.
- W1601557881 hasConcept C15744967 @default.
- W1601557881 hasConcept C171606756 @default.
- W1601557881 hasConcept C185592680 @default.
- W1601557881 hasConcept C199360897 @default.
- W1601557881 hasConcept C2776174256 @default.
- W1601557881 hasConcept C41008148 @default.
- W1601557881 hasConcept C49453240 @default.
- W1601557881 hasConcept C64943373 @default.
- W1601557881 hasConcept C70410870 @default.
- W1601557881 hasConcept C8171440 @default.
- W1601557881 hasConcept C86803240 @default.
- W1601557881 hasConcept C95444343 @default.
- W1601557881 hasConceptScore W1601557881C12554922 @default.
- W1601557881 hasConceptScore W1601557881C147789679 @default.
- W1601557881 hasConceptScore W1601557881C15744967 @default.
- W1601557881 hasConceptScore W1601557881C171606756 @default.
- W1601557881 hasConceptScore W1601557881C185592680 @default.
- W1601557881 hasConceptScore W1601557881C199360897 @default.
- W1601557881 hasConceptScore W1601557881C2776174256 @default.
- W1601557881 hasConceptScore W1601557881C41008148 @default.
- W1601557881 hasConceptScore W1601557881C49453240 @default.
- W1601557881 hasConceptScore W1601557881C64943373 @default.
- W1601557881 hasConceptScore W1601557881C70410870 @default.
- W1601557881 hasConceptScore W1601557881C8171440 @default.
- W1601557881 hasConceptScore W1601557881C86803240 @default.
- W1601557881 hasConceptScore W1601557881C95444343 @default.
- W1601557881 hasIssue "15" @default.
- W1601557881 hasLocation W16015578811 @default.
- W1601557881 hasOpenAccess W1601557881 @default.
- W1601557881 hasPrimaryLocation W16015578811 @default.
- W1601557881 hasRelatedWork W2003570266 @default.
- W1601557881 hasRelatedWork W2305072774 @default.
- W1601557881 hasRelatedWork W2317701797 @default.
- W1601557881 hasRelatedWork W2319809587 @default.
- W1601557881 hasRelatedWork W2416108297 @default.
- W1601557881 hasRelatedWork W2467787427 @default.
- W1601557881 hasRelatedWork W2606245082 @default.
- W1601557881 hasRelatedWork W986421643 @default.
- W1601557881 hasRelatedWork W1970315261 @default.
- W1601557881 hasRelatedWork W2461754875 @default.
- W1601557881 hasVolume "258" @default.
- W1601557881 isParatext "false" @default.
- W1601557881 isRetracted "false" @default.
- W1601557881 magId "1601557881" @default.
- W1601557881 workType "article" @default.