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- W1601596439 abstract "Introduction: Oral monotherapy with the direct factor Xa inhibitor edoxaban may facilitate initiation of anticoagulation for patients with newly diagnosed deep vein thrombosis (DVT). Hypothesis: We assessed the hypothesis that thrombus regression would be similar in patients with acute DVT treated with oral edoxaban monotherapy compared with low-molecular weight heparin (LMWH) and warfarin. Methods: We enrolled patients with acute symptomatic objectively-confirmed proximal DVT in an open-label multicenter trial and randomized them in a 2:1 ratio to edoxaban 90mg/day for 10 days followed by 60mg/day or LMWH/warfarin for a treatment duration of 3 months. The primary efficacy outcome was the relative change in magnetic resonance venogram (MRV)-quantified thrombus volume from baseline to Day 14-21. The primary safety outcome was major or clinically-relevant nonmajor bleeding. Results: Among 85 eligible patients randomized from 26 study sites, 56 were assigned to edoxaban, and 29 were assigned to LWMH/warfarin..." @default.
- W1601596439 created "2016-06-24" @default.
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- W1601596439 date "2014-11-25" @default.
- W1601596439 modified "2023-09-27" @default.
- W1601596439 title "Abstract 12074: A Randomized, Open-Label, Multicenter Study of the Efficacy and Safety of Edoxaban Monotherapy versus Low-Molecular Weight Heparin/Warfarin in Patients With Symptomatic Deep Vein Thrombosis - Edoxaban Thrombus Reduction Imaging Study (eTRIS)" @default.
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