FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W160167425> ?p ?o ?g. }

• W160167425 endingPage "620" @default.
• W160167425 startingPage "614" @default.
• W160167425 abstract "Radiation-induced meningiomas arise after low-dose irradiation treatment of certain medical conditions and are recognized as clinically separate from sporadic meningioma. These tumors are often aggressive or malignant, they are likely to be multiple, and they have a high recurrence rate following treatment compared with sporadic meningiomas. To understand the molecular mechanism by which radiation-induced meningioma (RIM) arise, we compared genetic changes in 7 RIM and 8 sporadic meningioma (SM) samples. The presence of mutations in the 17 exons of the neurofibromatosis type 2 (NF2) gene, which has been shown to be inactivated in sporadic meningiomas, was analyzed in RIM and SM using single-strand conformation polymorphism (SSCP) and DNA sequencing. In contrast to SM, which showed NF2 mutations in 50% of specimens, no mutations were found in RIM. In addition, Western blot analysis of schwannomin/merlin protein, the NF2 gene product, demonstrated protein levels comparable to normal brain in 4/4 RIM tumor samples analyzed. Loss of heterozygosity (LOH) of genomic regions, which were reported for SM, was also analyzed in all cases of RIM using 22 polymorphic DNA markers. Allele losses were found on chromosomes 1p (4/7), 9p (2/7), 19q (2/7), 22q (2/7), and 18q (1/7). From these observations we conclude that unlike sporadic meningiomas, NF2 gene inactivation and chromosome 22q deletions are far less frequent in RIM, and their role in meningioma development following low dose irradiation is less significant. Other chromosomal lesions, especially loss of 1p, possibly induced by irradiation, may be more important in the development of these tumors." @default.
• W160167425 created "2016-06-24" @default.
• W160167425 creator A5024898653 @default.
• W160167425 creator A5028420026 @default.
• W160167425 creator A5040030521 @default.
• W160167425 creator A5046690120 @default.
• W160167425 creator A5065263618 @default.
• W160167425 creator A5079808476 @default.
• W160167425 creator A5085672385 @default.
• W160167425 date "2000-07-01" @default.
• W160167425 modified "2023-09-26" @default.
• W160167425 title "Radiation-Induced Meningioma: A Distinct Molecular Genetic Pattern?" @default.
• W160167425 cites W1578132554 @default.
• W160167425 cites W1867918175 @default.
• W160167425 cites W1972474889 @default.
• W160167425 cites W1972617182 @default.
• W160167425 cites W1977910806 @default.
• W160167425 cites W1977951634 @default.
• W160167425 cites W1989274483 @default.
• W160167425 cites W1991201161 @default.
• W160167425 cites W2003862793 @default.
• W160167425 cites W2013646995 @default.
• W160167425 cites W2026549414 @default.
• W160167425 cites W2030098687 @default.
• W160167425 cites W2032848267 @default.
• W160167425 cites W2032896716 @default.
• W160167425 cites W2041025015 @default.
• W160167425 cites W2055656197 @default.
• W160167425 cites W2056221581 @default.
• W160167425 cites W2067690421 @default.
• W160167425 cites W2069777477 @default.
• W160167425 cites W2070491420 @default.
• W160167425 cites W2072103745 @default.
• W160167425 cites W2073532906 @default.
• W160167425 cites W2087716252 @default.
• W160167425 cites W2088868608 @default.
• W160167425 cites W2088978801 @default.
• W160167425 cites W2090482278 @default.
• W160167425 cites W2092044426 @default.
• W160167425 cites W2148621516 @default.
• W160167425 cites W2167850032 @default.
• W160167425 cites W2309042391 @default.
• W160167425 doi "https://doi.org/10.1093/jnen/59.7.614" @default.
• W160167425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10901233" @default.
• W160167425 hasPublicationYear "2000" @default.
• W160167425 type Work @default.
• W160167425 sameAs 160167425 @default.
• W160167425 citedByCount "87" @default.
• W160167425 countsByYear W1601674252012 @default.
• W160167425 countsByYear W1601674252013 @default.
• W160167425 countsByYear W1601674252014 @default.
• W160167425 countsByYear W1601674252015 @default.
• W160167425 countsByYear W1601674252017 @default.
• W160167425 countsByYear W1601674252020 @default.
• W160167425 countsByYear W1601674252021 @default.
• W160167425 countsByYear W1601674252022 @default.
• W160167425 countsByYear W1601674252023 @default.
• W160167425 crossrefType "journal-article" @default.
• W160167425 hasAuthorship W160167425A5024898653 @default.
• W160167425 hasAuthorship W160167425A5028420026 @default.
• W160167425 hasAuthorship W160167425A5040030521 @default.
• W160167425 hasAuthorship W160167425A5046690120 @default.
• W160167425 hasAuthorship W160167425A5065263618 @default.
• W160167425 hasAuthorship W160167425A5079808476 @default.
• W160167425 hasAuthorship W160167425A5085672385 @default.
• W160167425 hasBestOaLocation W1601674251 @default.
• W160167425 hasConcept C104317684 @default.
• W160167425 hasConcept C129219603 @default.
• W160167425 hasConcept C142724271 @default.
• W160167425 hasConcept C143589142 @default.
• W160167425 hasConcept C153911025 @default.
• W160167425 hasConcept C180754005 @default.
• W160167425 hasConcept C2778679214 @default.
• W160167425 hasConcept C2778984943 @default.
• W160167425 hasConcept C2779160599 @default.
• W160167425 hasConcept C30481170 @default.
• W160167425 hasConcept C36823959 @default.
• W160167425 hasConcept C502942594 @default.
• W160167425 hasConcept C54355233 @default.
• W160167425 hasConcept C71924100 @default.
• W160167425 hasConcept C86803240 @default.
• W160167425 hasConceptScore W160167425C104317684 @default.
• W160167425 hasConceptScore W160167425C129219603 @default.
• W160167425 hasConceptScore W160167425C142724271 @default.
• W160167425 hasConceptScore W160167425C143589142 @default.
• W160167425 hasConceptScore W160167425C153911025 @default.
• W160167425 hasConceptScore W160167425C180754005 @default.
• W160167425 hasConceptScore W160167425C2778679214 @default.
• W160167425 hasConceptScore W160167425C2778984943 @default.
• W160167425 hasConceptScore W160167425C2779160599 @default.
• W160167425 hasConceptScore W160167425C30481170 @default.
• W160167425 hasConceptScore W160167425C36823959 @default.
• W160167425 hasConceptScore W160167425C502942594 @default.
• W160167425 hasConceptScore W160167425C54355233 @default.
• W160167425 hasConceptScore W160167425C71924100 @default.
• W160167425 hasConceptScore W160167425C86803240 @default.
• W160167425 hasIssue "7" @default.
• W160167425 hasLocation W1601674251 @default.

• next