Matches in SemOpenAlex for { <https://semopenalex.org/work/W1601770727> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1601770727 abstract "SUMMARY. This study introduced a novel phase separation technique for the microencapsulation of metoprolol tartrate as a model. Non-solvent addition coacervation technique was employed for the loading of drug into ethylcellulose, a hydrophobic plastic polymer. Dichloromethane (DCM) and paraffin oil were employed as solvent and non-solvent, respectively. Microparticle batches abbreviated as M1, M2 and M3 were formulated by embedding 1 g of drug into 1 g, 2 g and 3 g of polymer, respectively followed by direct compression into tabletted microparticulate batches named a T1, T2 and T3, respectively. The drug and polymer remained intact in encapsulated form as confirmed by FTIR, XRD and DSC. However, a slight change in drug nature from crystalline to amorphous behavior and an endothermic peak for metoprolol tartrate at 130 oC was observed in drug and microparticle thermograms. Slightly aggregated spherical free flowing microparticles in a size range of 64 ?m-103 ?m were obtained. The entrapment efficiency ranged from 77% to 89%. The straight line obtained from a plot between square root of time (Hrs) versus percent drug release (%) and regression co-efficient (R2) confirmed that best fit model to all dissolution profiles was Higuchi’s model. The modes of drug release from microparticles and tabletted microparticles were Quasi-Fickian diffusion and anomalous diffusion, respectively. T3 was selected as an optimum formulation as its dissolution profile resembled (f2 = 76.25) Mepressor® (Novartis Pharma-Pakistan). The accelerated stability study, regarding dissolution behavior and drug contents, at 40oC/75% RH proved T3 stable in 40 oC/75% RH for six months. Non-solvent addition coacervation technique involving comparatively safe solvents such as dichloromethane and paraffin oil as solvent and non-solvent, respectively is a good techniques for the encapsulation of Biopharmaceutics Classification System class I drugs such as metoprolol tartrate." @default.
- W1601770727 created "2016-06-24" @default.
- W1601770727 creator A5007354148 @default.
- W1601770727 creator A5036537126 @default.
- W1601770727 creator A5042402324 @default.
- W1601770727 creator A5082563651 @default.
- W1601770727 creator A5086917368 @default.
- W1601770727 date "2010-01-01" @default.
- W1601770727 modified "2023-09-27" @default.
- W1601770727 title "Metoprolol tartrate-ethylcellulose tabletted microparticles: formulation and in vitro evaluation" @default.
- W1601770727 hasPublicationYear "2010" @default.
- W1601770727 type Work @default.
- W1601770727 sameAs 1601770727 @default.
- W1601770727 citedByCount "3" @default.
- W1601770727 countsByYear W16017707272012 @default.
- W1601770727 countsByYear W16017707272013 @default.
- W1601770727 crossrefType "journal-article" @default.
- W1601770727 hasAuthorship W1601770727A5007354148 @default.
- W1601770727 hasAuthorship W1601770727A5036537126 @default.
- W1601770727 hasAuthorship W1601770727A5042402324 @default.
- W1601770727 hasAuthorship W1601770727A5082563651 @default.
- W1601770727 hasAuthorship W1601770727A5086917368 @default.
- W1601770727 hasConcept C121332964 @default.
- W1601770727 hasConcept C127413603 @default.
- W1601770727 hasConcept C13965031 @default.
- W1601770727 hasConcept C14029885 @default.
- W1601770727 hasConcept C164705383 @default.
- W1601770727 hasConcept C178790620 @default.
- W1601770727 hasConcept C181389837 @default.
- W1601770727 hasConcept C185592680 @default.
- W1601770727 hasConcept C2776035855 @default.
- W1601770727 hasConcept C2777521759 @default.
- W1601770727 hasConcept C2780471494 @default.
- W1601770727 hasConcept C2781280847 @default.
- W1601770727 hasConcept C2909447574 @default.
- W1601770727 hasConcept C42360764 @default.
- W1601770727 hasConcept C43617362 @default.
- W1601770727 hasConcept C521977710 @default.
- W1601770727 hasConcept C69357855 @default.
- W1601770727 hasConcept C71924100 @default.
- W1601770727 hasConcept C77281830 @default.
- W1601770727 hasConcept C83029808 @default.
- W1601770727 hasConcept C88380143 @default.
- W1601770727 hasConcept C97355855 @default.
- W1601770727 hasConcept C98274493 @default.
- W1601770727 hasConceptScore W1601770727C121332964 @default.
- W1601770727 hasConceptScore W1601770727C127413603 @default.
- W1601770727 hasConceptScore W1601770727C13965031 @default.
- W1601770727 hasConceptScore W1601770727C14029885 @default.
- W1601770727 hasConceptScore W1601770727C164705383 @default.
- W1601770727 hasConceptScore W1601770727C178790620 @default.
- W1601770727 hasConceptScore W1601770727C181389837 @default.
- W1601770727 hasConceptScore W1601770727C185592680 @default.
- W1601770727 hasConceptScore W1601770727C2776035855 @default.
- W1601770727 hasConceptScore W1601770727C2777521759 @default.
- W1601770727 hasConceptScore W1601770727C2780471494 @default.
- W1601770727 hasConceptScore W1601770727C2781280847 @default.
- W1601770727 hasConceptScore W1601770727C2909447574 @default.
- W1601770727 hasConceptScore W1601770727C42360764 @default.
- W1601770727 hasConceptScore W1601770727C43617362 @default.
- W1601770727 hasConceptScore W1601770727C521977710 @default.
- W1601770727 hasConceptScore W1601770727C69357855 @default.
- W1601770727 hasConceptScore W1601770727C71924100 @default.
- W1601770727 hasConceptScore W1601770727C77281830 @default.
- W1601770727 hasConceptScore W1601770727C83029808 @default.
- W1601770727 hasConceptScore W1601770727C88380143 @default.
- W1601770727 hasConceptScore W1601770727C97355855 @default.
- W1601770727 hasConceptScore W1601770727C98274493 @default.
- W1601770727 hasLocation W16017707271 @default.
- W1601770727 hasOpenAccess W1601770727 @default.
- W1601770727 hasPrimaryLocation W16017707271 @default.
- W1601770727 hasRelatedWork W1644463378 @default.
- W1601770727 hasRelatedWork W2043066048 @default.
- W1601770727 hasRelatedWork W2052259228 @default.
- W1601770727 hasRelatedWork W2095546988 @default.
- W1601770727 hasRelatedWork W2096466629 @default.
- W1601770727 hasRelatedWork W2098628941 @default.
- W1601770727 hasRelatedWork W2114760320 @default.
- W1601770727 hasRelatedWork W2183429628 @default.
- W1601770727 hasRelatedWork W220937101 @default.
- W1601770727 hasRelatedWork W2265524899 @default.
- W1601770727 hasRelatedWork W2270680215 @default.
- W1601770727 hasRelatedWork W2278952487 @default.
- W1601770727 hasRelatedWork W2340203967 @default.
- W1601770727 hasRelatedWork W2605022711 @default.
- W1601770727 hasRelatedWork W3007774322 @default.
- W1601770727 hasRelatedWork W3170373383 @default.
- W1601770727 hasRelatedWork W2181302020 @default.
- W1601770727 hasRelatedWork W2593484633 @default.
- W1601770727 hasRelatedWork W2621262798 @default.
- W1601770727 hasRelatedWork W2947637339 @default.
- W1601770727 isParatext "false" @default.
- W1601770727 isRetracted "false" @default.
- W1601770727 magId "1601770727" @default.
- W1601770727 workType "article" @default.