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- W1601782018 abstract "A model for the estimation of pathway contributions has been extended to include the effect of the transaldolase reactions on the randomization of 14C of specifically labeled glucoses. With glucose-2-14C as substrate, the contribution of the pentose cycle to glucose metabolism and the extent of isomerization of fructose 6-phosphate to glucose 6-phosphate in a tissue represented by the model can be estimated solely from the distribution of 14C in the 6 carbon atoms of glucose 6-phosphate or a derivative. Data for adipose, adrenal, and thyroid tissue support the adequacy of this approach. In these tissues, the transaldolase exchange reaction, as well as the reaction of the pentose cycle catalyzed by transaldolase, appears to introduce 14C from glucose-2-14C into carbon atoms 4, 5, and 6 of hexose-6-P. The maximum rate of the transaldolase exchange reaction can be estimated. The transaldolase reactions do not affect estimates of pentose cycle contributions with glucose-1-14C and -6-14C when triose-P derivatives are employed, but do alter the relative specific activities in carbon atoms 1 to 6 of hexose-6-P derivatives." @default.
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- W1601782018 date "1966-02-01" @default.
- W1601782018 modified "2023-09-30" @default.
- W1601782018 title "Estimations of Pathway Contributions to Glucose Metabolism and the Transaldolase Reactions" @default.
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- W1601782018 doi "https://doi.org/10.1016/s0021-9258(18)96900-0" @default.
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