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- W1601809166 abstract "Objective: Decreased dehydroepiandrosterone (DHEA) levels are associated with endothelial dysfunction and increased cardiovascular mortality in postmenopausal women. Using ovariectomized rats, we first defined whether expression of sigma-1 receptor (Sig-1R) in the aorta is regulated following pressure overload (PO) and also after DHEA treatment. We also investigated effects of DHEA known as Sig-1R agonist on impaired Akt/endothelial nitric oxide synthase (eNOS) signaling in the thoracic aorta under PO. Research design/methods: Wistar rats subjected to bilateral ovariectomy (OVX) were further treated with abdominal aortic stenosis 2 weeks later. DHEA (15 and 30 mg/kg) was administered orally once a day for 14 days starting from 2 weeks after the aortic banding. Results: Time course study indicated that expression of Sig-1R expression and eNOS decreased time dependently in the thoracic aorta from 1 to 4 weeks after PO. DHEA treatment significantly inhibited the decreased Sig-1R expression in the thoracic aorta. The DHEA treatment also significantly restored PO-induced impaired Akt phosphorylation and stimulated eNOS protein expression with concomitant increased Akt-mediated eNOS phosphorylation (Ser1177). We did not find any changes in the phosphorylation of ERK1/2 and PKCα in the aorta following PO and after treatment with DHEA. Conclusion: We here reported, for the first time, that DHEA treatment induces the upregulation and stimulation of Sig-1R in the thoracic aorta that stimulate Sig-1R-mediated Akt-eNOS signaling pathways in ovariectomized rats under PO." @default.
- W1601809166 created "2016-06-24" @default.
- W1601809166 creator A5050137980 @default.
- W1601809166 creator A5055184036 @default.
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- W1601809166 date "2010-06-11" @default.
- W1601809166 modified "2023-09-23" @default.
- W1601809166 title "Dehydroepiandrosterone-Mediated Stimulation of Sigma-1 Receptor Activates Akt-eNOS Signaling in the Thoracic Aorta of Ovariectomized Rats with Abdominal Aortic Banding" @default.
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- W1601809166 doi "https://doi.org/10.1111/j.1755-5922.2010.00196.x" @default.
- W1601809166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20553277" @default.
- W1601809166 hasPublicationYear "2010" @default.
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