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• W1601855313 abstract "OBJECTIVE: To determine whether immune‐enhanced enteral nutrition (EN) was effective on nutritional status, immune function, surgical outcomes and days of hospitalization after total gastrectomy for patients with advanced gastric cancer (AGC). METHODS: From August 2005 to May 2011, 78 patients with AGC who underwent a total gastrectomy were enrolled and divided randomly into three groups: immune‐enhanced EN (EN + glutamine [Gln]) group, standard EN group and control group. Serum parameters including total protein, albumin, proalbumin and transferrin were examined on preoperative day 1, postoperative day 2 and day 12. Levels of immunoglobulin M (IgM), immunoglobulin G (IgG), natural killer (NK) cells, CD4 + and CD8 + T cells were also compared. RESULTS: The formulas were tolerated well in all the patients except 5 with mild complications. The EN + Gln and EN groups showed a faster onset of flatus and shorter hospitalization duration than the control group. On postoperative day 12, serum total protein, albumin, proalbumin and transferrin levels of the EN + Gln and EN groups were significantly higher than those of the control group ( P < 0.05). CD4 + T cells, NK cells, IgM and IgG levels of the EN + Gln group increased prominently, and were significantly higher than those before the operation as well as those in the EN and control groups. CONCLUSION: Immune‐enhanced EN can improve nutritional status and immune function for the patients with AGC after total gastrectomy." @default.
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• W1601855313 date "2012-07-13" @default.
• W1601855313 modified "2023-10-17" @default.
• W1601855313 title "Clinical application of immune-enhanced enteral nutrition in patients with advanced gastric cancer after total gastrectomy" @default.
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• W1601855313 doi "https://doi.org/10.1111/j.1751-2980.2012.00596.x" @default.
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