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- W1601935183 endingPage "19086" @default.
- W1601935183 startingPage "19070" @default.
- W1601935183 abstract "Significant advances have been achieved in recent years in the identification of the genetic and the molecular alterations of pancreatic ductal adenocarcinoma (PDAC). Despite this, at present the understanding of the precise mechanisms involved in the development and malignant transformation of PDAC remain relatively limited. Here, we evaluated for the first time, the molecular heterogeneity of PDAC tumors, through simultaneous assessment of the gene expression profile (GEP) for both coding and non-coding genes of tumor samples from 27 consecutive PDAC patients. Overall, we identified a common GEP for all PDAC tumors, characterized by an increased expression of genes involved in PDAC cell proliferation, local invasion and metastatic capacity, together with a significant alteration of the early steps of the cellular immune response. At the same time, we confirm and extend on previous observations about the genetic complexity of PDAC tumors as revealed by the demonstration of two clearly distinct and unique GEPs (e.g. epithelial-like vs. mesenchymal-like) reflecting the alteration of different signaling pathways involved in the oncogenesis and progression of these tumors. Our results also highlight the potential role of the immune system microenvironment in these tumors, with potential diagnostic and therapeutic implications." @default.
- W1601935183 created "2016-06-24" @default.
- W1601935183 creator A5004453681 @default.
- W1601935183 creator A5011977184 @default.
- W1601935183 creator A5014013713 @default.
- W1601935183 creator A5030383789 @default.
- W1601935183 creator A5044789897 @default.
- W1601935183 creator A5056695728 @default.
- W1601935183 creator A5063821031 @default.
- W1601935183 creator A5087149819 @default.
- W1601935183 creator A5088409474 @default.
- W1601935183 creator A5090056802 @default.
- W1601935183 date "2015-05-22" @default.
- W1601935183 modified "2023-10-16" @default.
- W1601935183 title "Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas" @default.
- W1601935183 cites W1505106591 @default.
- W1601935183 cites W1508844433 @default.
- W1601935183 cites W1525354012 @default.
- W1601935183 cites W1548935276 @default.
- W1601935183 cites W1587025242 @default.
- W1601935183 cites W1843651808 @default.
- W1601935183 cites W1965279152 @default.
- W1601935183 cites W1975290591 @default.
- W1601935183 cites W1977075884 @default.
- W1601935183 cites W1980516263 @default.
- W1601935183 cites W1981104423 @default.
- W1601935183 cites W1982001921 @default.
- W1601935183 cites W1985591743 @default.
- W1601935183 cites W1986626152 @default.
- W1601935183 cites W1988886103 @default.
- W1601935183 cites W1991888317 @default.
- W1601935183 cites W1993782263 @default.
- W1601935183 cites W1997585674 @default.
- W1601935183 cites W1997696802 @default.
- W1601935183 cites W1998605742 @default.
- W1601935183 cites W2000189255 @default.
- W1601935183 cites W2000420450 @default.
- W1601935183 cites W2001422697 @default.
- W1601935183 cites W2008541912 @default.
- W1601935183 cites W2013318867 @default.
- W1601935183 cites W2019459677 @default.
- W1601935183 cites W2022772800 @default.
- W1601935183 cites W2024466061 @default.
- W1601935183 cites W2026824540 @default.
- W1601935183 cites W2027210742 @default.
- W1601935183 cites W2030504358 @default.
- W1601935183 cites W2034683141 @default.
- W1601935183 cites W2044423100 @default.
- W1601935183 cites W2048000049 @default.
- W1601935183 cites W2048867608 @default.
- W1601935183 cites W2049647656 @default.
- W1601935183 cites W2050605814 @default.
- W1601935183 cites W2052494976 @default.
- W1601935183 cites W2053323838 @default.
- W1601935183 cites W2055085803 @default.
- W1601935183 cites W2056135332 @default.
- W1601935183 cites W2056143966 @default.
- W1601935183 cites W2059584025 @default.
- W1601935183 cites W2067544108 @default.
- W1601935183 cites W2067829376 @default.
- W1601935183 cites W2071199281 @default.
- W1601935183 cites W2072585972 @default.
- W1601935183 cites W2075731708 @default.
- W1601935183 cites W2078344286 @default.
- W1601935183 cites W2094211910 @default.
- W1601935183 cites W2095643532 @default.
- W1601935183 cites W2101117089 @default.
- W1601935183 cites W2103824791 @default.
- W1601935183 cites W2104146802 @default.
- W1601935183 cites W2108861663 @default.
- W1601935183 cites W2111916909 @default.
- W1601935183 cites W2117116688 @default.
- W1601935183 cites W2118797060 @default.
- W1601935183 cites W2123693778 @default.
- W1601935183 cites W2133586252 @default.
- W1601935183 cites W2134118500 @default.
- W1601935183 cites W2138155367 @default.
- W1601935183 cites W2138485734 @default.
- W1601935183 cites W2138550913 @default.
- W1601935183 cites W2141036465 @default.
- W1601935183 cites W2144459759 @default.
- W1601935183 cites W2147368820 @default.
- W1601935183 cites W2153349010 @default.
- W1601935183 cites W2153710117 @default.
- W1601935183 cites W2154458783 @default.
- W1601935183 cites W2154790710 @default.
- W1601935183 cites W2157795344 @default.
- W1601935183 cites W2159686118 @default.
- W1601935183 cites W2161884651 @default.
- W1601935183 cites W2162891726 @default.
- W1601935183 cites W2170989872 @default.
- W1601935183 cites W2175264619 @default.
- W1601935183 cites W2324600768 @default.
- W1601935183 cites W3193270327 @default.
- W1601935183 cites W4211246626 @default.
- W1601935183 cites W4294107304 @default.
- W1601935183 cites W45534775 @default.
- W1601935183 doi "https://doi.org/10.18632/oncotarget.4233" @default.