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• W1602034986 abstract "DNA is packaged into condensed chromatin fibers by association with histones and architectural proteins such as high mobility group (HMGB) proteins. However, this DNA packaging reduces accessibility of enzymes that act on DNA, such as proteins that process DNA after double strand breaks (DSBs). Chromatin remodeling overcomes this barrier. We show here that the Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence. HMO1 was evicted along with core histones during repair of DSBs, and chromatin remodeling events such as histone H2A phosphorylation and H3 eviction were faster in absence of HMO1. The facilitated chromatin remodeling in turn correlated with more efficient DNA resection and recruitment of repair proteins; for example, inward translocation of the DNA-end-binding protein Ku was faster in absence of HMO1. This chromatin stabilization requires the lysine-rich C-terminal extension of HMO1 as truncation of the HMO1 C-terminal tail phenocopies hmo1 deletion. Since this is reminiscent of the need for the basic C-terminal domain of mammalian histone H1 in chromatin compaction, we speculate that HMO1 promotes chromatin stability by DNA bending and compaction imposed by its lysine-rich domain and that it must be evicted along with core histones for efficient DSB repair." @default.
• W1602034986 created "2016-06-24" @default.
• W1602034986 creator A5000308807 @default.
• W1602034986 creator A5012467017 @default.
• W1602034986 creator A5083725105 @default.
• W1602034986 date "2015-05-15" @default.
• W1602034986 modified "2023-09-23" @default.
• W1602034986 title "Yeast high mobility group protein HMO1 stabilizes chromatin and is evicted during repair of DNA double strand breaks" @default.
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• W1602034986 doi "https://doi.org/10.1093/nar/gkv498" @default.
• W1602034986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4499126" @default.
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• W1602034986 hasPublicationYear "2015" @default.
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