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- W1602094685 abstract "This chapter discusses PTEN and Mytobularins, families of Phosphoinositides phosphatases, playing crucial roles in a variety of complex cellular processes. The involvement of phosphoinositides in such a striking number of physiologic processes has led to intensive study of the protein effectors, including lipid kinases and phosphatases that control the spatial and temporal levels of these signaling molecules. PTEN was initially identified as a human tumor suppressor gene located on chromosome 10q23.3, a region frequently mutated in human brain, prostrate, kidney, and breast cancers. The myotubularins represent a second family of protein tyrosine phosphatase-like enzymes that utilize inositol lipids as physiologic substrates. Myotubularin (MTM1), the archetypical member of this group of phosphatases, was initially identified in patients with X-linked, recessive myotubular myopathy, a severe congenital disorder in which muscle cell development is compromised. The chapter describes methodologies that are successful in assessing the lipid phosphatase activity of PTEN and myotubularin family enzymes. These approaches are useful as they can readily be adapted to analyze the activity of most any lipid phosphatases by simply altering simple reaction parameters such as pH, ionic strength, and substrate concentration." @default.
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- W1602094685 date "2003-01-01" @default.
- W1602094685 modified "2023-10-18" @default.
- W1602094685 title "PTEN and Myotubularins: Families of Phosphoinositide Phosphatases" @default.
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- W1602094685 doi "https://doi.org/10.1016/s0076-6879(03)66004-0" @default.
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