FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1602116268> ?p ?o ?g. }

• W1602116268 endingPage "518" @default.
• W1602116268 startingPage "509" @default.
• W1602116268 abstract "Some studies report that the positive relationship between L‐type Ca 2+ current ( I Ca−L ) and frequency in cardiac myocytes is mainly due to a direct negative feedback of sarcoplasmic reticulum Ca 2+ release on I Ca−L inactivation while others provide evidence for activation of calmodulin kinase II (CaMKII). To further elucidate the role of endogenous CaMKII activity, the CaMKII inhibitory peptides, autocamtide‐2 relating inhibitory peptide (AIP) and myristoylated AIP were applied using conventional and perforated patch‐clamp methods. AIP inhibited the normal adaptive increase in I Ca−L in response to abrupt increase in pacing frequency from 0.05 to 2 Hz. The positive I Ca−L –frequency relationship was reversed by AIP and the inhibitory effect of AIP was significantly exaggerated at fast pacing rates. The onset of inactivation of I Ca−L was not altered by AIP. After thapsigargin treatment, AIP slowed recovery from inactivation of I Ca−L and this effect was exaggerated during fast pacing. Buffering of [Ca 2+ ] i by BAPTA and EGTA accelerated recovery of I Ca−L from inactivation, and BAPTA partly eliminated the effect of AIP on the recovery. We conclude that: (1) [Ca 2+ ] i directly slows I Ca−L recovery from inactivation; and (2) Ca 2+ ‐dependent endogenous CaMKII activity accelerates the I Ca−L recovery. Thus, at fast heart rates, elevated [Ca 2+ ] i activates endogenous CaMKII and compensates for its direct inhibitory effect on I Ca−L recovery from inactivation. Dynamic activity of endogenous CaMKII enhances the positive I Ca−L –frequency relationship." @default.
• W1602116268 created "2016-06-24" @default.
• W1602116268 creator A5062652150 @default.
• W1602116268 creator A5064555547 @default.
• W1602116268 date "2006-07-06" @default.
• W1602116268 modified "2023-10-18" @default.
• W1602116268 title "Calmodulin kinase II accelerates L‐type Ca²⁺ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca²⁺]_i in rat ventricular myocytes" @default.
• W1602116268 cites W1601307541 @default.
• W1602116268 cites W1628979938 @default.
• W1602116268 cites W1670760110 @default.
• W1602116268 cites W1973472018 @default.
• W1602116268 cites W1986158212 @default.
• W1602116268 cites W1999764967 @default.
• W1602116268 cites W2001594716 @default.
• W1602116268 cites W2003470377 @default.
• W1602116268 cites W2016448886 @default.
• W1602116268 cites W2034371514 @default.
• W1602116268 cites W2056183098 @default.
• W1602116268 cites W2056481979 @default.
• W1602116268 cites W2058449890 @default.
• W1602116268 cites W2080321050 @default.
• W1602116268 cites W2086871275 @default.
• W1602116268 cites W2087062865 @default.
• W1602116268 cites W2108383919 @default.
• W1602116268 cites W2119825205 @default.
• W1602116268 cites W2124374208 @default.
• W1602116268 cites W2135011583 @default.
• W1602116268 cites W2135846312 @default.
• W1602116268 cites W2139060480 @default.
• W1602116268 cites W2151769410 @default.
• W1602116268 cites W2152757383 @default.
• W1602116268 cites W2157343215 @default.
• W1602116268 cites W2168556429 @default.
• W1602116268 cites W2218211815 @default.
• W1602116268 cites W4293179290 @default.
• W1602116268 cites W97375708 @default.
• W1602116268 doi "https://doi.org/10.1113/jphysiol.2006.109199" @default.
• W1602116268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1817774" @default.
• W1602116268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16627565" @default.
• W1602116268 hasPublicationYear "2006" @default.
• W1602116268 type Work @default.
• W1602116268 sameAs 1602116268 @default.
• W1602116268 citedByCount "35" @default.
• W1602116268 countsByYear W16021162682012 @default.
• W1602116268 countsByYear W16021162682013 @default.
• W1602116268 countsByYear W16021162682014 @default.
• W1602116268 countsByYear W16021162682015 @default.
• W1602116268 countsByYear W16021162682016 @default.
• W1602116268 countsByYear W16021162682017 @default.
• W1602116268 countsByYear W16021162682018 @default.
• W1602116268 countsByYear W16021162682019 @default.
• W1602116268 countsByYear W16021162682020 @default.
• W1602116268 countsByYear W16021162682021 @default.
• W1602116268 countsByYear W16021162682022 @default.
• W1602116268 countsByYear W16021162682023 @default.
• W1602116268 crossrefType "journal-article" @default.
• W1602116268 hasAuthorship W1602116268A5062652150 @default.
• W1602116268 hasAuthorship W1602116268A5064555547 @default.
• W1602116268 hasBestOaLocation W16021162681 @default.
• W1602116268 hasConcept C12554922 @default.
• W1602116268 hasConcept C126322002 @default.
• W1602116268 hasConcept C134018914 @default.
• W1602116268 hasConcept C158617107 @default.
• W1602116268 hasConcept C16613235 @default.
• W1602116268 hasConcept C17077164 @default.
• W1602116268 hasConcept C178790620 @default.
• W1602116268 hasConcept C181199279 @default.
• W1602116268 hasConcept C185592680 @default.
• W1602116268 hasConcept C2777146706 @default.
• W1602116268 hasConcept C2777658833 @default.
• W1602116268 hasConcept C2780019300 @default.
• W1602116268 hasConcept C29688787 @default.
• W1602116268 hasConcept C519063684 @default.
• W1602116268 hasConcept C55493867 @default.
• W1602116268 hasConcept C71924100 @default.
• W1602116268 hasConcept C79879829 @default.
• W1602116268 hasConcept C86803240 @default.
• W1602116268 hasConceptScore W1602116268C12554922 @default.
• W1602116268 hasConceptScore W1602116268C126322002 @default.
• W1602116268 hasConceptScore W1602116268C134018914 @default.
• W1602116268 hasConceptScore W1602116268C158617107 @default.
• W1602116268 hasConceptScore W1602116268C16613235 @default.
• W1602116268 hasConceptScore W1602116268C17077164 @default.
• W1602116268 hasConceptScore W1602116268C178790620 @default.
• W1602116268 hasConceptScore W1602116268C181199279 @default.
• W1602116268 hasConceptScore W1602116268C185592680 @default.
• W1602116268 hasConceptScore W1602116268C2777146706 @default.
• W1602116268 hasConceptScore W1602116268C2777658833 @default.
• W1602116268 hasConceptScore W1602116268C2780019300 @default.
• W1602116268 hasConceptScore W1602116268C29688787 @default.
• W1602116268 hasConceptScore W1602116268C519063684 @default.
• W1602116268 hasConceptScore W1602116268C55493867 @default.
• W1602116268 hasConceptScore W1602116268C71924100 @default.
• W1602116268 hasConceptScore W1602116268C79879829 @default.
• W1602116268 hasConceptScore W1602116268C86803240 @default.
• W1602116268 hasIssue "2" @default.
• W1602116268 hasLocation W16021162681 @default.
• W1602116268 hasLocation W16021162682 @default.

• next