Matches in SemOpenAlex for { <https://semopenalex.org/work/W1602162225> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1602162225 endingPage "15" @default.
- W1602162225 startingPage "15" @default.
- W1602162225 abstract "Non-mass forming, neoplastic intraepithelial proliferations (dysplasia) represent the most well-accepted precursor lesions to gallbladder adenocarcinomas. They are typically small, localized, grossly unrecognizable lesions that have been identified in the epithelium adjacent to up to 79% of gallbladder adenocarcinomas. Morphologic variants that have been reported include flat, micropapillary, papillary and cribriform. We have recently encountered a morphologically distinctive, previously unreported lesion to which we have applied the designation eosinophilic dysplasia. This lesion was identified in a gallbladder with diffuse mural fibrosis and calcification (porcelain gallbladder). The dysplastic focus was confined to one tissue section, and was comprised of a localized true papilla [i.e with a fibrovascular core], measuring approximately 1.2 mm in greatest dimension and an adjacent, flat, 7-cell epithelial segment. These foci were lined by cells displaying significant nuclear enlargement [1.5-4 times the adjacent benign cells], nuclear pleomorphism, occasional multinucleation, hyperchromasia and nuclear membrane irregularities. Nucleoli were present but inconspicuous. These cells also showed voluminous eosinophilic to granular cytoplasm, such that the overall nuclear-to-cytoplasmic ratio was generally not increased. The cells displayed diffuse and marked nuclear immunoreactivity for p53, and approximately 70% of the cells showed nuclear positivity for Ki-67. The cells were also positive for cytokeratin 7 and were entirely negative for carcinoembryonic antigen (CEA) and chromogranin A. The cells of the adjacent normal epithelium were positive for cytokeratin 7 and CEA, negative for p53 and chromogranin A and showed a Ki-67 labeling index of <10%. Marked overexpression of the p53 protein as well as its high proliferative index are strong arguments in favor of the dysplastic nature of this lesion. However, further studies are required to elucidate its true clinical significance and to determine whether or not its association with a porcelain gallbladder, as noted herein, is entirely fortuitous. However, such studies can only be performed with an increased recognition by practitioners of this distinctive variant." @default.
- W1602162225 created "2016-06-24" @default.
- W1602162225 creator A5043669779 @default.
- W1602162225 creator A5085756280 @default.
- W1602162225 date "2006-01-01" @default.
- W1602162225 modified "2023-09-23" @default.
- W1602162225 cites W1976093435 @default.
- W1602162225 cites W2002029824 @default.
- W1602162225 cites W2003895963 @default.
- W1602162225 cites W2015311622 @default.
- W1602162225 cites W2035733003 @default.
- W1602162225 cites W2052503468 @default.
- W1602162225 cites W2057166634 @default.
- W1602162225 cites W2058990157 @default.
- W1602162225 cites W2068278190 @default.
- W1602162225 cites W2073519741 @default.
- W1602162225 cites W2109125167 @default.
- W1602162225 cites W2111902674 @default.
- W1602162225 cites W2146889894 @default.
- W1602162225 cites W2341890494 @default.
- W1602162225 cites W2411358875 @default.
- W1602162225 cites W56372391 @default.
- W1602162225 cites W2414237673 @default.
- W1602162225 doi "https://doi.org/10.1186/1746-1596-1-15" @default.
- W1602162225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1555612" @default.
- W1602162225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16879748" @default.
- W1602162225 hasPublicationYear "2006" @default.
- W1602162225 type Work @default.
- W1602162225 sameAs 1602162225 @default.
- W1602162225 citedByCount "7" @default.
- W1602162225 countsByYear W16021622252013 @default.
- W1602162225 countsByYear W16021622252016 @default.
- W1602162225 countsByYear W16021622252017 @default.
- W1602162225 countsByYear W16021622252019 @default.
- W1602162225 countsByYear W16021622252020 @default.
- W1602162225 crossrefType "journal-article" @default.
- W1602162225 hasAuthorship W1602162225A5043669779 @default.
- W1602162225 hasAuthorship W1602162225A5085756280 @default.
- W1602162225 hasBestOaLocation W16021622251 @default.
- W1602162225 hasConcept C141071460 @default.
- W1602162225 hasConcept C142724271 @default.
- W1602162225 hasConcept C204232928 @default.
- W1602162225 hasConcept C2775894508 @default.
- W1602162225 hasConcept C2777148285 @default.
- W1602162225 hasConcept C2779012181 @default.
- W1602162225 hasConcept C2779758542 @default.
- W1602162225 hasConcept C2781289014 @default.
- W1602162225 hasConcept C2910118542 @default.
- W1602162225 hasConcept C529295009 @default.
- W1602162225 hasConcept C71924100 @default.
- W1602162225 hasConcept C77231918 @default.
- W1602162225 hasConcept C86803240 @default.
- W1602162225 hasConceptScore W1602162225C141071460 @default.
- W1602162225 hasConceptScore W1602162225C142724271 @default.
- W1602162225 hasConceptScore W1602162225C204232928 @default.
- W1602162225 hasConceptScore W1602162225C2775894508 @default.
- W1602162225 hasConceptScore W1602162225C2777148285 @default.
- W1602162225 hasConceptScore W1602162225C2779012181 @default.
- W1602162225 hasConceptScore W1602162225C2779758542 @default.
- W1602162225 hasConceptScore W1602162225C2781289014 @default.
- W1602162225 hasConceptScore W1602162225C2910118542 @default.
- W1602162225 hasConceptScore W1602162225C529295009 @default.
- W1602162225 hasConceptScore W1602162225C71924100 @default.
- W1602162225 hasConceptScore W1602162225C77231918 @default.
- W1602162225 hasConceptScore W1602162225C86803240 @default.
- W1602162225 hasIssue "1" @default.
- W1602162225 hasLocation W16021622251 @default.
- W1602162225 hasLocation W16021622252 @default.
- W1602162225 hasLocation W16021622253 @default.
- W1602162225 hasLocation W16021622254 @default.
- W1602162225 hasOpenAccess W1602162225 @default.
- W1602162225 hasPrimaryLocation W16021622251 @default.
- W1602162225 hasRelatedWork W1602162225 @default.
- W1602162225 hasRelatedWork W1988545048 @default.
- W1602162225 hasRelatedWork W2028147463 @default.
- W1602162225 hasRelatedWork W2081252687 @default.
- W1602162225 hasRelatedWork W2155481399 @default.
- W1602162225 hasRelatedWork W2162800570 @default.
- W1602162225 hasRelatedWork W2205133608 @default.
- W1602162225 hasRelatedWork W2373149062 @default.
- W1602162225 hasRelatedWork W3040570474 @default.
- W1602162225 hasRelatedWork W3023648694 @default.
- W1602162225 hasVolume "1" @default.
- W1602162225 isParatext "false" @default.
- W1602162225 isRetracted "false" @default.
- W1602162225 magId "1602162225" @default.
- W1602162225 workType "article" @default.