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- W1602408490 abstract "This chapter summarizes the various strategies used by the microbes against the immune defenses of the host cell. Many infections that are restricted to body surfaces have short incubation periods, with less than a week between initial infection and disease onset. The microbe thus evades the immune response by completing its growth and shedding within a few days before the host deploys specific antibody and T cells. Immunological tolerance is another factor that reduces the immune response to a given antigen. There is commonly a degree of tolerance to a microorganism when infection occurs during fetal or early postnatal life. Tolerance to a given microorganism can also arise when large amounts of microbial antigen or antigen-antibody complexes are circulating in the body. If a microbial antigen is very similar to normal host antigens, the immune response to this antigen may be weak or absent, giving a degree of tolerance. A large variety of microorganisms causes immunosuppression in the infected host, i.e., the host shows a depressed immune response to antigens unrelated to those of the infecting microorganism. Some of the other strategies include, latent phase of the microbes, microbial presence in bodily sites inaccessible to the immune response, induction of inappropriate antibody and T-cell responses, antibodies mopped up by soluble microbial antigens, and antigenic variations." @default.
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- W1602408490 date "1995-01-01" @default.
- W1602408490 modified "2023-09-27" @default.
- W1602408490 title "Microbial Strategies in Relation to the Immune Response" @default.
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- W1602408490 doi "https://doi.org/10.1016/b978-0-12-498262-8.50014-x" @default.
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