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• W1602534233 abstract "Immunoliposomes represent a rational strategy to achieve targeted drug delivery for cancer treatment. This chapter summarizes the recent developments in the use of immunoliposomes for cancer treatment. Because of their improved pharmacologic properties, sterically stabilized liposomes have generated renewed interest in liposomes as drug carriers. Sterically stabilized liposomes containing doxorubicin have shown encouraging clinical activity. Immunoliposomes (ILs) represent a further strategy to enhance liposomal drug delivery, by linking liposomes to monoclonal antibodies (MAbs) directed against tumor-associated antigens. Sterically stabilized immunoliposomes directed against tumor-associated antigens have been used to target murine squamous cell lung cancer cells in vitro and in vivo and murine fibrosarcoma cells in vitro. Immunoliposomes designed for intraperitoneal therapy have been used to target human ovarian cancer cells in vitro and in ascites fluid in vivo. In addition to targeting tumor-associated an igens, immunoliposomes have been developed to target endothelial cells. Anti-HER2 immunoliposome-mediated delivery of doxorubicin may represent a particularly advantageous strategy for the treatment of breast and other cancers with frequent HER2 overexpression. Moreover, anti-HER2 immunoliposome delivery of doxorubicin provides a means of limiting the toxicity of doxorubicin in normal tissues. Immunoliposomes may prove useful as a tumor-targeted delivery system for a variety of anticancer agents, such as doxorubicin, by increasing tumor exposure and reducing toxicity to normal cells and tissues. In addition to targeted delivery of small molecule drugs, improvements in immunoliposome design and construction may lead to new therapeutic applications, such as gene therapy." @default.
• W1602534233 created "2016-06-24" @default.
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• W1602534233 date "1997-01-01" @default.
• W1602534233 modified "2023-10-06" @default.
• W1602534233 title "Immunoliposomes for Cancer Treatment" @default.
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• W1602534233 doi "https://doi.org/10.1016/s1054-3589(08)60146-5" @default.
• W1602534233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9217932" @default.
• W1602534233 hasPublicationYear "1997" @default.
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