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- W1602658503 abstract "The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex. In the present study, we examined the roles of N-methyl-D-aspartate (NMDA) receptors in this seizure model. The intraperitoneal administration of the competitive NMDA receptor blocker DL-2-amino-7-phosphonoheptanoic acid (36 and 72 mg/kg) and the non-competitive NMDA receptor blocker MK-801 (1.35 and 2.7 mg/kg), completely prevented the induction of seizure and bradyarrhythmia or sudden death resulting from seizure. Therefore, the white-noise-induced seizures in Mg-deficient rats are linked to increased neuronal excitability via the NMDA receptor." @default.
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- W1602658503 date "1994-03-01" @default.
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- W1602658503 title "In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by receptor blockers" @default.
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- W1602658503 doi "https://doi.org/10.1016/0920-1211(94)90055-8" @default.
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