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- W1602682754 abstract "Due to its proto-oncogene nature, c-Src is the SFK most frequently associated with malignancy (Yeatman, 2004). Over 100 years ago, Peyton Rous observed that injection of cell-free extracts from tumours grown in chickens caused the development of the same type of tumour in host animals. This observation prompted the hypothesis that a filterable agent was the cause of the tumour (Rous, 1911a, 1911b). In support of this notion, in 1955 Rubin showed that the Rous’filterable agent was a virus, called Rous Sarcoma Virus (RSV), which was found to play a direct role in inducing cell malignancy (Rubin, 1955). In the ‘60s and ‘70s, the tools of modern molecular biology provided the genetic definition of v-Src, a viral oncogene included within the RSV genome. v-Src was observed not to be required for virus replication but to be the causative agent of cancer (Martin, 1970; Duesberg & Vogt, 1970). Shortly thereafter, it was shown that v-Src had a counterpart in eukaryotic cells, named c-Src (Takeda and Hanafusa, 1983). c-Src is involved in many physiological functions of the cells. It carries a regulatory domain lacking in v-Src (Fig. 1), therefore, its activity is under tight molecular control. c-Src was the first of several proto-oncogenes discovered in the vertebrate genome and, in 1989, this discovery earned Bishop and Varmus the Nobel Prize in Physiology or Medicine, for the description of “the cellular origin of retroviral oncogenes”." @default.
- W1602682754 created "2016-06-24" @default.
- W1602682754 creator A5001875881 @default.
- W1602682754 creator A5011506319 @default.
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- W1602682754 date "2012-06-05" @default.
- W1602682754 modified "2023-09-26" @default.
- W1602682754 title "The Crucial Role of c-Src Tyrosine Kinase in Bone Metabolism" @default.
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