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- W1602704565 abstract "SUMMARY Small RNAs impact several cellular processes through gene regulation. Argonaute proteins bind small RNAs to form effector complexes that control transcriptional and post‐transcriptional gene expression. PIWI proteins belong to the Argonaute protein family, and bind PIWI‐interacting RNAs (piRNAs). They are highly abundant in the germline, but are also expressed in some somatic tissues. The PIWI/piRNA pathway has a role in transposon repression in Drosophila, which occurs both by epigenetic regulation and post‐transcriptional degradation of transposon mRNAs. These functions are conserved, but clear differences in the extent and mechanism of transposon repression exist between species. Mutations in piwi genes lead to the upregulation of transposon mRNAs. It is hypothesized that this increased transposon mobilization leads to genomic instability and thus sterility, although no causal link has been established between transposon upregulation and genome instability. An alternative scenario could be that piwi mutations directly affect genomic instability, and thus lead to increased transposon expression. We propose that the PIWI/piRNA pathway controls genome stability in several ways: suppression of transposons, direct regulation of chromatin architecture and regulation of genes that control important biological processes related to genome stability. The PIWI/piRNA pathway also regulates at least some, if not many, protein‐coding genes, which further lends support to the idea that piwi genes may have broader functions beyond transposon repression. An intriguing possibility is that the PIWI/piRNA pathway is using transposon sequences to coordinate the expression of large groups of genes to regulate cellular function. Mol. Reprod. Dev. 80:632–664, 2013. © 2013 Wiley Periodicals, Inc ." @default.
- W1602704565 created "2016-06-24" @default.
- W1602704565 creator A5022775509 @default.
- W1602704565 creator A5084515555 @default.
- W1602704565 date "2013-06-27" @default.
- W1602704565 modified "2023-10-18" @default.
- W1602704565 title "Untangling the web: The diverse functions of the PIWI/piRNA pathway" @default.
- W1602704565 cites W1426240221 @default.
- W1602704565 cites W1490789146 @default.
- W1602704565 cites W1773519674 @default.
- W1602704565 cites W1845807280 @default.
- W1602704565 cites W1912524364 @default.
- W1602704565 cites W1952594807 @default.
- W1602704565 cites W1965368044 @default.
- W1602704565 cites W1966150502 @default.
- W1602704565 cites W1968616490 @default.
- W1602704565 cites W1969142635 @default.
- W1602704565 cites W1969632113 @default.
- W1602704565 cites W1970698209 @default.
- W1602704565 cites W1971549481 @default.
- W1602704565 cites W1973596898 @default.
- W1602704565 cites W1973886143 @default.
- W1602704565 cites W1974141543 @default.
- W1602704565 cites W1974423729 @default.
- W1602704565 cites W1976342457 @default.
- W1602704565 cites W1977532365 @default.
- W1602704565 cites W1977733607 @default.
- W1602704565 cites W1978712536 @default.
- W1602704565 cites W1979333307 @default.
- W1602704565 cites W1979919958 @default.
- W1602704565 cites W1980462131 @default.
- W1602704565 cites W1981473563 @default.
- W1602704565 cites W1984842308 @default.
- W1602704565 cites W1986641814 @default.
- W1602704565 cites W1987332588 @default.
- W1602704565 cites W1987721914 @default.
- W1602704565 cites W1987908533 @default.
- W1602704565 cites W1990654003 @default.
- W1602704565 cites W1991435353 @default.
- W1602704565 cites W1992397255 @default.
- W1602704565 cites W1994429466 @default.
- W1602704565 cites W1994833459 @default.
- W1602704565 cites W1996321460 @default.
- W1602704565 cites W1998255410 @default.
- W1602704565 cites W1998297488 @default.
- W1602704565 cites W1999901063 @default.
- W1602704565 cites W2001040475 @default.
- W1602704565 cites W2002708668 @default.
- W1602704565 cites W2003663539 @default.
- W1602704565 cites W2003981507 @default.
- W1602704565 cites W2004271888 @default.
- W1602704565 cites W2004305619 @default.
- W1602704565 cites W2006169630 @default.
- W1602704565 cites W2008951002 @default.
- W1602704565 cites W2009431145 @default.
- W1602704565 cites W2009644747 @default.
- W1602704565 cites W2009957319 @default.
- W1602704565 cites W2010596106 @default.
- W1602704565 cites W2010916267 @default.
- W1602704565 cites W2011832929 @default.
- W1602704565 cites W2013163897 @default.
- W1602704565 cites W2013883400 @default.
- W1602704565 cites W2015231728 @default.
- W1602704565 cites W2015402753 @default.
- W1602704565 cites W2015423672 @default.
- W1602704565 cites W2015858554 @default.
- W1602704565 cites W2019806092 @default.
- W1602704565 cites W2021243703 @default.
- W1602704565 cites W2023844789 @default.
- W1602704565 cites W2026570758 @default.
- W1602704565 cites W2026584449 @default.
- W1602704565 cites W2027726975 @default.
- W1602704565 cites W2028444170 @default.
- W1602704565 cites W2028498299 @default.
- W1602704565 cites W2029078135 @default.
- W1602704565 cites W2029185292 @default.
- W1602704565 cites W2030256602 @default.
- W1602704565 cites W2033149076 @default.
- W1602704565 cites W2034161629 @default.
- W1602704565 cites W2034311538 @default.
- W1602704565 cites W2035303830 @default.
- W1602704565 cites W2035864975 @default.
- W1602704565 cites W2035930185 @default.
- W1602704565 cites W2037172992 @default.
- W1602704565 cites W2037570580 @default.
- W1602704565 cites W2038288403 @default.
- W1602704565 cites W2038521536 @default.
- W1602704565 cites W2039684583 @default.
- W1602704565 cites W2040092655 @default.
- W1602704565 cites W2040577960 @default.
- W1602704565 cites W2041306541 @default.
- W1602704565 cites W2041389365 @default.
- W1602704565 cites W2043094718 @default.
- W1602704565 cites W2043472480 @default.
- W1602704565 cites W2044126921 @default.
- W1602704565 cites W2044545834 @default.
- W1602704565 cites W2046318418 @default.
- W1602704565 cites W2046691210 @default.