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- W1602724116 abstract "In aqueous environment, amphiphilic molecules (viz., surfactants, drugs, polymers, etc.) or ions are frequently assemble at interfaces and self-associate in an attempt to sequester their apolar regions from contact with the aqueous phase (Attwood & Florence, 1983, Atherton & Barry, 1985, Attwood et al, 1989, Schreier et al, 2000, Attwood, 1995a,1995b, Mandal & Nair, 1988, 1991, Mandal et al, 1987, 1993, Geetha et al, 1993, 2003, Mandal, 1993, Mandal & Jayakumar, 1994, Geetha & Mandal, 1997a, 1997b, 2000, Rose & Mandal, 1996, Taboada et al, 2000, 2001, Junquera et al, 2001, Rodriguez et al, 2004, Misra et al, 2009, 2010, James et al, 2011, James & Mandal 2011, Mandal et al, 2010, Tiwary et al, 2011, Alam et al, 2007, Khan et al, 2009, 2010). A large number of drug molecules are amphiphilic and self-associate in aqueous solution to form small aggregates. These surface-active behavior among many diverse classes of drugs has been reported and attempts have been made to correlate surface activity and biological activity (Attwood & Florence, 1983, Atherton & Barry, 1985, Attwood et al, 1989, Schreier et al, 2000, Taboada et al, 2000, Junquera et al, 2001, Attwood, 1995, Geetha et al, 2003, Alam et al, 2007, 2008). The aggregation of the above drugs follows the same principles as of conventional surfactants (Schreier et al, 2000, Taboada et al, 2000, Junquera et al, 2001, Attwood, 1995, Geetha et al, 2003, Alam et al, 2007, 2008). The selfassociation of drug depends on the molecular structure of the drug, its concentration and the experimental conditions such as temperature, pH and salt concentration (Atherton & Barry, 1985, Taboada et al, 2000, Junquera et al, 2001, Attwood, 1995, Geetha et al, 2003, Alam et al, 2007, 2008). The “surfactant-like” behavior of these drugs is due to the presence of an almost planar tricyclic ring system and a short hydrocarbon chain carrying a terminal nitrogen atom (Taboada et al, 2000, Junquera et al, 2001). The self-assembly and self-organization are natural and spontaneous processes, occurring mainly through non-covalent interactions such as, van der Waals, hydrogen-bonding," @default.
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- W1602724116 date "2011-10-10" @default.
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- W1602724116 title "Thermodynamics of Amphiphilic Drug Imipramine Hydrochloride in Presence of Additives" @default.
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- W1602724116 doi "https://doi.org/10.5772/25158" @default.
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