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- W1602911910 abstract "The direct separation of isomeric glucuronide metabolites from propranolol dosed tissue extracts by differential mobility spectrometry-mass spectrometry (DMS-MS) with the use of the polar gas-phase chemical modifier acetonitrile was demonstrated. The DMS gas-phase separation was able to resolve the isomeric metabolites with separation times on the order of milliseconds instead of minutes which is typically required when using pre-ionization chromatographic separation methods. Direct separation of isomeric metabolites from the complex tissue extract was confirmed by implementing a high-performance liquid chromatography (HPLC) separation prior to the DMS-MS analysis to pre-separate the species of interest. The ability to separate isomeric exogenous metabolites directly from a complex tissue extract is expected to facilitate the drug development process by increasing analytical throughput without the requirement for pre-ionization cleanup or separation strategies." @default.
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- W1602911910 date "2011-10-10" @default.
- W1602911910 modified "2023-10-18" @default.
- W1602911910 title "Rapid analysis of isomeric exogenous metabolites by differential mobility spectrometry - mass spectrometry" @default.
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- W1602911910 doi "https://doi.org/10.1002/rcm.5238" @default.
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