Matches in SemOpenAlex for { <https://semopenalex.org/work/W1603009452> ?p ?o ?g. }
- W1603009452 abstract "Globally, hepatocellular carcinoma (HCC) is the fifth most common cancer and the third highest cause of cancer-associated deaths. Although the development of HCC has been linked to exposure to various toxins or infectious agents, the majority of HCC cases are associated with chronic hepatitis B virus (HBV) infections [reviewed in (Block et al, 2003; Seeger et al, 2007)]. Worldwide, there are an estimated 350 million cases of chronic HBV infections, and approximately 25% of chronically HBV-infected individuals will eventually develop HCC [(Beasley et al, 1981); reviewed in (Seeger et al, 2007)]. The high global incidence of chronic HBV infections, high mortality rate of individuals with HCC, increased prevalence of HCC, and the close association between chronic HBV infections and HCC development have generated intense interest in understanding the molecular mechanisms that underlie the development of HBV-induced HCC. In this chapter, we provide a review of HBV biology and potential mechanisms that link a chronic HBV infection to the development of HCC. We specifically focus on activities of the HBV X protein (HBx), a multifunctional HBV protein that can alter hepatocyte physiology and stimulate HBV replication. While a brief survey of HBx activities that could influence HCC development is provided, we emphasize HBx regulation of intracellular calcium signaling and cell proliferation pathways as HBx activities that could potentially influence hepatocyte transformation." @default.
- W1603009452 created "2016-06-24" @default.
- W1603009452 creator A5001927864 @default.
- W1603009452 creator A5044040961 @default.
- W1603009452 creator A5066225947 @default.
- W1603009452 creator A5082766986 @default.
- W1603009452 date "2012-02-10" @default.
- W1603009452 modified "2023-10-16" @default.
- W1603009452 title "Modulation of Cell Proliferation Pathways by the Hepatitis B Virus X Protein: A Potential Contributor to the Development of Hepatocellular Carcinoma" @default.
- W1603009452 cites W119892048 @default.
- W1603009452 cites W1437949713 @default.
- W1603009452 cites W1485297825 @default.
- W1603009452 cites W1507923077 @default.
- W1603009452 cites W1508483754 @default.
- W1603009452 cites W1518642595 @default.
- W1603009452 cites W1521115099 @default.
- W1603009452 cites W1525178335 @default.
- W1603009452 cites W1553235593 @default.
- W1603009452 cites W1555714030 @default.
- W1603009452 cites W158638529 @default.
- W1603009452 cites W1591152328 @default.
- W1603009452 cites W1599277155 @default.
- W1603009452 cites W1623494770 @default.
- W1603009452 cites W1635667563 @default.
- W1603009452 cites W1640179935 @default.
- W1603009452 cites W1651425720 @default.
- W1603009452 cites W1667463872 @default.
- W1603009452 cites W1796170190 @default.
- W1603009452 cites W1813513289 @default.
- W1603009452 cites W1822891345 @default.
- W1603009452 cites W1823105562 @default.
- W1603009452 cites W1866772708 @default.
- W1603009452 cites W1875430957 @default.
- W1603009452 cites W189153698 @default.
- W1603009452 cites W1892608609 @default.
- W1603009452 cites W1892996323 @default.
- W1603009452 cites W1920479129 @default.
- W1603009452 cites W1931669582 @default.
- W1603009452 cites W194707462 @default.
- W1603009452 cites W1963791094 @default.
- W1603009452 cites W1966071985 @default.
- W1603009452 cites W1966254490 @default.
- W1603009452 cites W1967204456 @default.
- W1603009452 cites W1967799787 @default.
- W1603009452 cites W1967847365 @default.
- W1603009452 cites W1968050352 @default.
- W1603009452 cites W1968297570 @default.
- W1603009452 cites W1969743834 @default.
- W1603009452 cites W1969939692 @default.
- W1603009452 cites W1970237293 @default.
- W1603009452 cites W1970337657 @default.
- W1603009452 cites W1972249702 @default.
- W1603009452 cites W1974540308 @default.
- W1603009452 cites W1975092706 @default.
- W1603009452 cites W1975324295 @default.
- W1603009452 cites W1975873758 @default.
- W1603009452 cites W1978245389 @default.
- W1603009452 cites W1978922109 @default.
- W1603009452 cites W1979027806 @default.
- W1603009452 cites W1980166477 @default.
- W1603009452 cites W1980896697 @default.
- W1603009452 cites W1981268203 @default.
- W1603009452 cites W1981349080 @default.
- W1603009452 cites W1982622947 @default.
- W1603009452 cites W1983420558 @default.
- W1603009452 cites W1984412842 @default.
- W1603009452 cites W1985022589 @default.
- W1603009452 cites W1985563243 @default.
- W1603009452 cites W1986150533 @default.
- W1603009452 cites W1986676942 @default.
- W1603009452 cites W1987046538 @default.
- W1603009452 cites W1987536971 @default.
- W1603009452 cites W1989312510 @default.
- W1603009452 cites W1989501772 @default.
- W1603009452 cites W1990980578 @default.
- W1603009452 cites W1991101546 @default.
- W1603009452 cites W1991530019 @default.
- W1603009452 cites W1993384459 @default.
- W1603009452 cites W1995289527 @default.
- W1603009452 cites W1996413533 @default.
- W1603009452 cites W1996711919 @default.
- W1603009452 cites W1997018082 @default.
- W1603009452 cites W1997551404 @default.
- W1603009452 cites W1997615901 @default.
- W1603009452 cites W1998039589 @default.
- W1603009452 cites W1998284663 @default.
- W1603009452 cites W1998420703 @default.
- W1603009452 cites W1999824658 @default.
- W1603009452 cites W2001593061 @default.
- W1603009452 cites W2002674120 @default.
- W1603009452 cites W2004154055 @default.
- W1603009452 cites W2004234324 @default.
- W1603009452 cites W2005186431 @default.
- W1603009452 cites W2005383067 @default.
- W1603009452 cites W2005790594 @default.
- W1603009452 cites W2008381783 @default.
- W1603009452 cites W2011848967 @default.
- W1603009452 cites W2013580109 @default.
- W1603009452 cites W2014163855 @default.
- W1603009452 cites W2014475340 @default.